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Type: Artigo
Title: Pulp obliteration in a patient with sclerodermatous chronic graft-versus-host disease
Author: Gomes, Camilla Borges Ferreira
Treister, Nathaniel Simon
Miller, Brian
Armand, Philippe
Friedland, Bernard
Abstract: Dental pulp calcification is a common finding associated with localized dental trauma, genetic disorders, and systemic inflammatory diseases. Chronic graft-versus-host disease (cGVHD) is a frequent complication after allogeneic hematopoietic cell transplantation (allo-HCT) characterized by immune-mediated injury to the skin, mouth, eyes, liver, and other tissues, resulting in significant disability and reduced quality of life. We report a patient with sclerodermatous cGVHD who presented with general pulp calcification in all teeth 5 years after allo-HCT. A review of full mouth dental radiographs obtained just before allo-HCT revealed normal-appearing pulp chambers. Based on prior reports of generalized pulp calcification associated with progressive systemic sclerosis, we hypothesized that the etiology was likely related to the presence of cGVHD with associated vascular and fibrotic tissue changes within the pulp vasculature. Clinicians should consider cGVHD in the differential diagnosis of generalized pulp calcification
Subject: Transplante de células-tronco hematopoéticas
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.joen.2016.01.009
Date Issue: 2016
Appears in Collections:FOP - Artigos e Outros Documentos

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