Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354925
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMontalvão, Silmara-
dc.contributor.authorunicampTucunduva, Alini Camargo-
dc.contributor.authorunicampSiqueira, Lúcia Helena de-
dc.contributor.authorunicampMedina, Samuel de Souza-
dc.contributor.authorunicampOzelo, Margareth Castro-
dc.typeArtigopt_BR
dc.titleA longitudinal evaluation of anti‐FVIII antibodies demonstrated IgG4 subclass is mainly correlated with high‐titre inhibitor in haemophilia a patientspt_BR
dc.contributor.authorMontalvão, S. A. L.-
dc.contributor.authorTucunduva, A. C.-
dc.contributor.authorSiqueira, L. H.-
dc.contributor.authorSambo, A. L. A.-
dc.contributor.authorMedina, S. S.-
dc.contributor.authorOzelo, M. C.-
dc.subjectImunoglobulinaspt_BR
dc.subject.otherlanguageImmunoglobulinspt_BR
dc.description.abstractThe development of inhibitory antibodies against factor VIII (FVIII) (inhibitor) is the major complication in haemophilia A patients. The FVIII‐binding antibodies development comprises a polyclonal immunoglobulin (Ig) G response. Recent studies showed strong correlation between the presence of neutralizing anti‐FVIII antibodies (inhibitors) and IgG4 subclass. The aim of this study was to evaluate anti‐FVIII IgG subclasses in haemophilia A patients with inhibitor both in a cross‐sectional and in a longitudinal analysis. Inhibitors were determined by Nijmegen–Bethesda assay. Anti‐FVIII IgG subclasses were performed by ELISA, and samples from 20 healthy individuals were used to validate the test. We studied 25 haemophilia A patients with inhibitor, previously treated exclusively with plasma‐derived FVIII concentrates or bypassing agents. The IgG subclasses distributions were evaluated in two groups of patients classified according to inhibitor response. IgG1 and IgG4 antibodies were most prominent in haemophilia A patients with inhibitors when compared with IgG2 and IgG3. This study reports for the first time the behaviour of FVIII‐binding IgG1 and IgG4 subclasses in a longitudinal analysis, in a clinical setting, of high‐response inhibitor haemophilia A patients, showing the correlation of IgG4 and the inhibitor titres. In spite of being considered a non‐pathologic antibody subclass with anti‐inflammatory properties in other situations, IgG4 is correlated with the presence of high‐titre inhibitor in the haemophilia setting. The comprehension of the IgG4 role in immune response may be crucial to establish the process for designing specific tolerance to FVIIIpt_BR
dc.relation.ispartofHaemophiliapt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2015-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume21pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage686pt_BR
dc.description.lastpage692pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1351-8216pt_BR
dc.identifier.eissn1365-2516pt_BR
dc.identifier.doi10.1111/hae.12646pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/hae.12646pt_BR
dc.date.available2021-01-28T21:20:10Z-
dc.date.accessioned2021-01-28T21:20:10Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2021-01-28T21:20:10Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-26T13:23:21Z : No. of bitstreams: 1 000362446700043.pdf: 315962 bytes, checksum: 61b9a0f46d3bb436e4e72d4acd7a7922 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-28T21:20:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354925-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.identifier.source000362446700043pt_BR
dc.creator.orcid0000-0002-8920-3765pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-5938-0675pt_BR
dc.type.formArtigo originalpt_BR
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HEMO - Artigos e Outros Documentos

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