Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354909
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPires-de-Campos, Maria Silvia Mariani-
dc.contributor.authorunicampAlmeida, Juliana de-
dc.contributor.authorunicampNunes, Valéria Wolf-
dc.contributor.authorunicampFrancesconi, Elaine Patricia Maltez Souza-
dc.contributor.authorunicampGrassi-Kassisse, Dora Maria-
dc.typeArtigopt_BR
dc.titleUltrasound associated with caffeine increases basal and beta-adrenoceptor response in adipocytes isolated from subcutaneous adipose tissue in pigspt_BR
dc.contributor.authorPires-de-Campos, Maria Silvia Mariani-
dc.contributor.authorAlmeida, Juliana De-
dc.contributor.authorWolf-Nunes, Valéria-
dc.contributor.authorSouza-Francesconi, Elaine-
dc.contributor.authorGrassi-Kassisse, Dora Maria-
dc.subjectIsoproterenolpt_BR
dc.subjectGlicerolpt_BR
dc.subject.otherlanguageGlycerolpt_BR
dc.subject.otherlanguageIsoproterenolpt_BR
dc.description.abstractThe topical use of caffeine has been indicated for the lipodystrophies treatment as it promotes increased lipolysis. Ultrasound (US) is often used in cutaneous diseases, esthetic conditions, and as a skin permeation enhancer. We investigate the lipolytic response of adipocytes isolated from subcutaneous adipose pigs tissue subjected to treatment with topical application of phonophoresis associated with caffeine. We treated dorsal regions of pigs (Landrace × Large White, 35 days, 15 kg, n = 6) daily for 15 days with gel, gel + US [3 MHz, continuous, 0.2 Wcm2, 1 min/cm2, in total 2 min], gel + caffeine (5%w/w), and gel + caffeine + US. We used a fifth untreated region as control. Twenty-four hours after the last application, we isolated the adipocytes of each treated area and quantified the basal and stimulated lipolytic responses to isoprenaline. The results, in μmol glycerol/106cells/60 min, were analyzed with analysis of variance or ANOVA followed by Newman–Keuls test. The value of p < 0.05 was indicative of statistical difference. Only the adipocytes isolated from the area treated with caffeine + US showed increased basal lipolysis (0.76 ± 0.26; p = 0.0276) and maximal isoprenaline stimulation (0.38 ± 0.15, p = 0.0029) compared with the other areas. The results demonstrate that increased lipolysis of caffeine + US is due to an increase in basal and beta-adrenoceptor response by caffeine, and caffeine's effect is local, avoiding unwanted effects.pt_BR
dc.relation.ispartofJournal of cosmetic and laser therapypt_BR
dc.publisher.cityAbingdonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherTaylor & Francispt_BR
dc.date.issued2016-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume18pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage116pt_BR
dc.description.lastpage123pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1476-4172pt_BR
dc.identifier.eissn1476-4180pt_BR
dc.identifier.doi10.3109/14764172.2015.1063659pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.3109/14764172.2015.1063659pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-01-28T19:45:56Z-
dc.date.accessioned2021-01-28T19:45:56Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-01-28T19:45:56Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-01-28T19:45:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354909-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordTopical agentspt_BR
dc.identifier.source000372891600015pt_BR
dc.creator.orcid0000-0001-8187-5930pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-9864-7405pt_BR
dc.type.formArtigo originalpt_BR
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