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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMendes, Maria Carolina Santos-
dc.contributor.authorunicampPimentel, Gustavo Duarte-
dc.contributor.authorunicampCosta, Felipe Osório-
dc.contributor.authorunicampCarvalheira, José Barreto Campello-
dc.typeArtigopt_BR
dc.titleMolecular and neuroendocrine mechanisms of cancer cachexiapt_BR
dc.contributor.authorMendes, Maria Carolina S-
dc.contributor.authorPimentel, Gustavo D-
dc.contributor.authorCosta, Felipe O-
dc.contributor.authorCarvalheira, José B C-
dc.subjectTumores neuroendócrinospt_BR
dc.subject.otherlanguageNeuroendocrine tumorspt_BR
dc.description.abstractCancer and its morbidities, such as cancer cachexia, constitute a major public health problem. Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial and complex physiopathology has hindered the understanding of its mechanism. During the last few decades we have witnessed a dramatic increase in the understanding of cancer cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main features of cancer cachexia. These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatmentpt_BR
dc.relation.ispartofJournal of endocrinologypt_BR
dc.relation.ispartofabbreviationJ. endocrinol.pt_BR
dc.publisher.cityBristolpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherBioScientificapt_BR
dc.date.issued2015-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume226pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpageR29pt_BR
dc.description.lastpageR43pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-0795pt_BR
dc.identifier.eissn1479-6805pt_BR
dc.identifier.doi10.1530/JOE-15-0170pt_BR
dc.identifier.urlhttps://joe.bioscientifica.com/configurable/contentpage/journals$002fjoe$002f226$002f3$002fR29.xmlpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber306821/2010-9pt_BR
dc.description.sponsordocumentnumber2013/07607-8; 2014/22347-5pt_BR
dc.date.available2021-01-28T17:29:22Z-
dc.date.accessioned2021-01-28T17:29:22Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2021-01-28T17:29:22Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-26T13:23:20Z : No. of bitstreams: 1 000360941600002.pdf: 470278 bytes, checksum: bf3a867817fa287b96e0954b9e14b2c8 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-28T17:29:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354896-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000360941600002pt_BR
dc.creator.orcid0000-0002-2442-1956pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-0136-0943pt_BR
dc.type.formArtigopt_BR
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