Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354892
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMamián López, Mónica Benicia-
dc.contributor.authorunicampPoppi, Ronei Jesus-
dc.typeArtigopt_BR
dc.titleSERS hyperspectral imaging assisted by MCR-ALS for studying polymeric microfilms loaded with paracetamolpt_BR
dc.contributor.authorMamián-López, Mónica B.-
dc.contributor.authorPoppi, Ronei J.-
dc.subjectImagem hiperespectralpt_BR
dc.subject.otherlanguageHyperspectral imagingpt_BR
dc.description.abstractIn this study, a combination of the high detectability and specificity of the SERS technique with powerful chemometric tools was used to obtain hyperspectral images in order to assess the chemical distribution of the components of polymeric microfilms loaded with paracetamol as active principle. Four microfilms with drug content ranging between 5.42 and 18.62% were fabricated directly over nanostructured gold substrates and spectra were acquired over an area of 4 × 4 mm. Chemical images were first built following a qualitative approach by applying principal component analysis (PCA) and calculating correlation coefficients. With the algorithm multivariate curve resolution–alternating least squares (MCR-ALS), the mean concentrations of all components were calculated with relative error values between 3.5 and 4.9% for paracetamol. With the proposed methodology, both qualitative and quantitative assessments of the distribution of constituents of polymeric microfilms were successfully performed. In addition, physical-chemistry interactions among them could be also analyzedpt_BR
dc.relation.ispartofMicrochemical journalpt_BR
dc.relation.ispartofabbreviationMicrochem j.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume123pt_BR
dc.description.firstpage243pt_BR
dc.description.lastpage251pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0026-265Xpt_BR
dc.identifier.eissn1095-9149pt_BR
dc.identifier.doi10.1016/j.microc.2015.07.003pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0026265X1500140Xpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber573672/2008-3pt_BR
dc.description.sponsordocumentnumber33003017007P0pt_BR
dc.description.sponsordocumentnumber08/57805-2pt_BR
dc.date.available2021-01-28T17:01:12Z-
dc.date.accessioned2021-01-28T17:01:12Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-01-28T17:01:12Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-03-08T18:37:08Z : No. of bitstreams: 1 000360512100034.pdf: 3148464 bytes, checksum: 24eedf8f9946beca0e0381a483247690 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-28T17:01:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354892-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Analíticapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordSurface-enhanced Raman spectroscopypt_BR
dc.subject.keywordPolymeric filmspt_BR
dc.subject.keywordMultivariate curve resolutionpt_BR
dc.subject.keywordParacetamolpt_BR
dc.identifier.source000360512100034pt_BR
dc.creator.orcid0000-0003-2040-7804pt_BR
dc.creator.orcid0000-0003-2994-0787pt_BR
dc.type.formArtigopt_BR
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