Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354848
Type: Artigo
Title: The total synthesis of calcium atorvastatin
Author: Dias, Luiz C.
Vieira, Adriano S.
Barreiro, Eliezer J.
Abstract: A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boronmediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
Subject: Atorvastatina
Cálcio
Country: Estados Unidos
Editor: Royal Society of Chemistry
Rights: Fechado
Identifier DOI: 10.1039/c5ob02546j
Address: https://pubs.rsc.org/en/content/articlelanding/2016/ob/c5ob02546j#
Date Issue: 2015
Appears in Collections:IQ - Artigos e Outros Documentos

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