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Type: Outro documento
Title: Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone
Author: Khan, Ismat Ullah
Kattela, Shivashankar
Hassana, Abbas
Correia, Carlos Roque Duarte
Abstract: A novel, efficient and enantioselective Heck–Matsuda desymmetrization of non-activated cyclopentene-fused spiro-pyrrolidinones was developed. The reaction provided the Heck products in good to excellent yields and selectivities and tolerated a variety of functional groups in arenediazonium tetrafluoroborates (12 examples) with respect to its electronics and substitution patterns. This methodology was successfully applied in the concise enantioselective total synthesis of VPC01091 (2b), a drug candidate for the treatment of multiple sclerosis.
Subject: Esfingosina
Country: Estados Unidos
Editor: Royal Society of Chemistry
Rights: Fechado
Identifier DOI: 10.1039/c6ob01892k
Date Issue: 2016
Appears in Collections:IQ - Artigos e Outros Documentos

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