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Type: Artigo
Title: Chemical composition of the essential oil from the leaves of Anaxagorea brevipes (Annonaceae) and evaluation of its bioactivity
Author: Alencar, Danielle Cardoso de
Pinheiro, Maria Lúcia Belém
Pereira, José Lamak da Silva
Carvalho, João Ernesto de
Campos, Francinete Ramos
Serain, Alessandra Freitas
Tirico, Ricardo Brunelli
Hernández-Tasco, Alvaro José
Costa, Emmanoel Vilaça
Salvador, Marcos José
Abstract: The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC–FID) and coupled to mass spectrometry (GC–MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were β-eudesmol (13.16%), α-eudesmol (13.05%), γ-eudesmol (7.54%), guaiol (5.12%), caryophyllene oxide (4.18%) and β-bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100 μg/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI = 12.8 μg/mL), NCI-H460 (lung, TGI = 13.0 μg/mL) and PC-3 (prostate, TGI = 9.6 μg/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8 μg/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517 μmol TE/g). This is the first report regarding the chemical composition and bioactivity of A. brevipes essential oil.
Subject: Annonaceae
Essências e óleos essenciais
Country: Reino Unido
Editor: Taylor & Francis
Rights: Fechado
Identifier DOI: 10.1080/14786419.2015.1101103
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
CPQBA - Artigos e Outros Documentos

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