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|Title:||Increased activity of MMP-2 In hypertensive obese children is associated with hypoadiponectinemia|
|Author:||Belo, Vanessa A.|
Miranda, Josiane A.
Lanna, Carla M. M.
Souza-Costa, Debora C.
Tanus-Santos, Jose E.
|Abstract:||To compare the circulating levels of MMP-2 and TIMP-2 and the MMP-2/TIMP-2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP-2 and TIMP-2 levels and MMP-2/TIMP-2 ratios. Studies were carried out with 53 control, 73 obese, and 29 obese hypertensive children and adolescents in this cross-sectional study. Adiponectin and TIMP-2 concentrations were measured by ELISA. MMP-2 concentrations were measured by gelatin zymography. Multiple linear regression analysis was carried out to assess the effects of adiponectin on MMP-2 and TIMP-2 levels and MMP-2/TIMP-2 ratios. The obese hypertensive group had the lowest adiponectin levels among groups (P<0.05) while obese subjects had lower adiponectin levels than control subjects (P<0.05). Obese hypertensive subjects also had higher circulating MMP-2 concentrations than obese subjects (P<0.05) and had the highest MMP-2/TIMP-2 ratios among groups (P<0.05). Moreover, obese/hypertensive subjects had the lowest TIMP-2 levels among groups (P<0.05). A multiple linear regression analysis showed that MMP-2 levels and MMP-2/TIMP-2 ratios are negatively associated with adiponectin levels (P=0.034 and P=0.011, respectively) while TIMP-2 levels is positively associated with adiponectin levels (P=0.013). Increased activity of MMP-2 (MMP-2/TIMP-2 ratio) and reduced TIMP-2 levels may play an important role in clinical hypertension of childhood obesity. Additionally, hypoadiponectinemia may contribute to increased activity of MMP-2 in obese/hypertensive children and adolescents|
|Subject:||Metaloproteinase 2 da matriz|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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