Please use this identifier to cite or link to this item:
Type: Artigo
Title: The Tam receptor mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
Author: Miner, Jonathan J.
Daniels, Brian P.
Shrestha, Bimmi
Proenca-Modena, Jose L.
Lew, Erin D.
Lazear, Helen M.
Gorman, Matthew J.
Lemke, Greg
Klein, Robyn S.
Diamond, Michael S.
Abstract: The TAM receptors Tyro3, Axl and Mertk are receptor tyrosine kinases that dampen host innate immune responses following engagement with their ligands Gas6 and Protein S, which recognize phosphatidylserine on apoptotic cells. In a form of apoptotic mimicry, many enveloped viruses display phosphatidylserine on the outer leaflet of their membranes, enabling TAM receptor activation and downregulation of antiviral responses. Accordingly, we hypothesized that a deficiency of TAM receptors would enhance antiviral responses and protect against viral infection. Unexpectedly, mice lacking Mertk and/or Axl, but not Tyro3, exhibited greater vulnerability to infection with neuroinvasive West Nile and La Crosse encephalitis viruses. This phenotype was associated with increased blood-brain barrier permeability, which enhanced virus entry into and infection of the brain. Activation of Mertk synergized with interferon-b to tighten cell junctions and prevent virus transit across brain microvascular endothelial cells. Because TAM receptors restrict pathogenesis of neuroinvasive viruses, these findings have implications for TAM antagonists that are currently in clinical development
Subject: Sistema nervoso central
Proteínas tirosina quinases
Vírus do Nilo Ocidental
Resposta imune
Country: Estados Unidos
Editor: Nature
Rights: Fechado
Identifier DOI: 10.1038/nm.3974
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000366008700017.pdf1.48 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.