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|Title:||Refractory and resistant hypertension: characteristics and differences observed in a specialized clinic|
Faria, Ana Paula de
Sabbatini, Andréa Rodrigues
Barbaro, Natália Ruggeri
Ritter, Alessandra M. V.
|Abstract:||Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite the use of ≥3 anti–hypertensive drugs, or controlled requiring use of ≥4 drugs. Recently, a new definition for an extreme phenotype of RH (uncontrolled BP using at least five drugs) has emerged—the refractory hypertension (RfH). Although characteristics of RH are well established, little is known about this newly described subgroup. For this work, 116 subjects with RH were enrolled from a specialized clinic and divided into RH (n = 80) and RfH (n = 36). Subjects were submitted to echocardiography, 24–hour ambulatory BP measurement and biochemical analyses. Logistic regression analysis demonstrated that: (1) white–coat effect (odds ratio [OR], 3.23; 95% confidence interval [CI], 1.12–9.27; P = .03), (2) black race (OR, 6.67; 95% CI, 1.99–16.16; P < .001), and (3) left ventricular mass index (OR, 1.02; 95% CI, 1.01–1.03; P = .04) were independent predictors of refractoriness. In conclusion, RfH and RH present different patient characteristics, and these phenotypic aspects can be useful for better understanding this harder–to–treat subgroup|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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