Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354597
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampZago, Vanessa Helena de Souza-
dc.contributor.authorunicampParra, Eliane Soler-
dc.contributor.authorunicampScherrer, Daniel Zanetti-
dc.contributor.authorunicampPanzoldo, Natália Baratella-
dc.contributor.authorunicampAlexandre, Fernanda-
dc.contributor.authorunicampFaria, Eliana Cotta de-
dc.typeArtigopt_BR
dc.titleAssociation between ABCG1 polymorphism rs1893590 and high-density lipoprotein (HDL) in an asymptomatic Brazilian populationpt_BR
dc.contributor.authorZago, V. H. S.-
dc.contributor.authorScherrer, D. Z.-
dc.contributor.authorParra, E. S.-
dc.contributor.authorPanzoldo, N. B.-
dc.contributor.authorAlexandre, F.-
dc.contributor.authorNakandakare, E. R.-
dc.contributor.authorQuintão, E. C. R.-
dc.contributor.authorFaria, E. C. de-
dc.subjectPolimorfismo (Genética)pt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.description.abstractATP binding cassette transporter G1 (ABCG1) promotes lipidation of nascent high-density lipoprotein (HDL) particles, acting as an intracellular transporter. SNP rs1893590 (c.-204A > C) of ABCG1 gene has been previously studied and reported as functional over plasma HDL-C and lipoprotein lipase activity. This study aimed to investigate the relationships of SNP rs1893590 with plasma lipids and lipoproteins in a large Brazilian population. Were selected 654 asymptomatic and normolipidemic volunteers from both genders. Clinical and anthropometrical data were taken and blood samples were drawn after 12 h fasting. Plasma lipids and lipoproteins, as well as HDL particle size and volume were determined. Genomic DNA was isolated for SNP rs1893590 detection by TaqMan® OpenArray® Real-Time PCR Plataform (Applied Biosystems). Mann–Whitney U, Chi square and two-way ANOVA were the used statistical tests. No significant differences were found in the comparison analyses between the allele groups for all studied parameters. Conversely, significant interactions were observed between SNP and age over plasma HDL-C, were volunteers under 60 years with AA genotype had increased HDL-C (p = 0.048). Similar results were observed in the group with body mass index (BMI) < 25 kg/m2, where volunteers with AA genotype had higher HDL-C levels (p = 0.0034), plus an increased HDL particle size (p = 0.01). These findings indicate that SNP rs1893590 of ABCG1 has a significant impact over HDL-C under asymptomatic clinical conditions in an age and BMI dependent waypt_BR
dc.relation.ispartofMolecular biology reports: an international journal on molecular and cellular biologypt_BR
dc.relation.ispartofabbreviationMol. biol. rep.pt_BR
dc.publisher.cityDordrechtpt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2015-
dc.language.isoengpt_BR
dc.description.volume42pt_BR
dc.description.firstpage745pt_BR
dc.description.lastpage754pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0301-4851pt_BR
dc.identifier.eissn1573-4978pt_BR
dc.identifier.doi10.1007/s11033-014-3823-0pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007/s11033-014-3823-0pt_BR
dc.date.available2021-01-22T12:56:03Z-
dc.date.accessioned2021-01-22T12:56:03Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2021-01-22T12:56:03Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-26T13:23:15Z : No. of bitstreams: 1 000349986600019.pdf: 669924 bytes, checksum: 8117ceecd38f94a9ef505c96adbc12a5 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-22T12:56:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354597-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Patologia Clínicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordLipoprotein (HDL)pt_BR
dc.identifier.source000349986600019pt_BR
dc.creator.orcid0000-0003-2488-0199pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5208-1274pt_BR
dc.type.formArtigopt_BR
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