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http://repositorio.unicamp.br/jspui/handle/REPOSIP/354570
Type: | Artigo |
Title: | A fully disposable paper-based electrophoresis microchip with integrated pencil-drawn electrodes for contactless conductivity detection |
Author: | Chagas, Cyro L. S. Souza, Fabrício R. de Cardoso, Thiago M. G. Moreira, Roger C. Silva, José A. F. da Jesus, Dosil P. de Coltro, Wendell K. T. |
Abstract: | We describe for the first time the fabrication of a paper-based microchip electrophoresis (pME) device with integrated hand-drawn pencil electrodes to perform capacitively coupled contactless conductivity detection (C4D). This low-cost device (less than $0.10) revealed great capability to dissipate heat, good injection-to-injection repeatability, and ease of attaching pencil-drawn electrodes on the separation channel. The feasibility of the proposed pME-C4D device was successfully demonstrated with the separation of bovine serum albumin and creatinine within 150 s with baseline resolution. The limits of detection values for albumin and creatinine were 20 and 35 μmol L−1, respectively. These biomolecules present clinical relevance as evidence of kidney failure. The proposed pME-C4D offers great potential to be explored in the diagnosis of diabetes mellitus and heart disease |
Subject: | Eletroforese |
Country: | Reino Unido |
Editor: | Royal Society of Chemistry |
Rights: | Aberto |
Identifier DOI: | 10.1039/c6ay01963c |
Address: | https://pubs.rsc.org/en/content/articlelanding/2016/AY/C6AY01963C |
Date Issue: | 2016 |
Appears in Collections: | IQ - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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000393584100002.pdf | 570 kB | Adobe PDF | View/Open |
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