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Type: Artigo
Title: A fully disposable paper-based electrophoresis microchip with integrated pencil-drawn electrodes for contactless conductivity detection
Author: Chagas, Cyro L. S.
Souza, Fabrício R. de
Cardoso, Thiago M. G.
Moreira, Roger C.
Silva, José A. F. da
Jesus, Dosil P. de
Coltro, Wendell K. T.
Abstract: We describe for the first time the fabrication of a paper-based microchip electrophoresis (pME) device with integrated hand-drawn pencil electrodes to perform capacitively coupled contactless conductivity detection (C4D). This low-cost device (less than $0.10) revealed great capability to dissipate heat, good injection-to-injection repeatability, and ease of attaching pencil-drawn electrodes on the separation channel. The feasibility of the proposed pME-C4D device was successfully demonstrated with the separation of bovine serum albumin and creatinine within 150 s with baseline resolution. The limits of detection values for albumin and creatinine were 20 and 35 μmol L−1, respectively. These biomolecules present clinical relevance as evidence of kidney failure. The proposed pME-C4D offers great potential to be explored in the diagnosis of diabetes mellitus and heart disease
Subject: Eletroforese
Country: Reino Unido
Editor: Royal Society of Chemistry
Rights: Aberto
Identifier DOI: 10.1039/c6ay01963c
Date Issue: 2016
Appears in Collections:IQ - Artigos e Outros Documentos

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