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|Title:||A fully disposable paper-based electrophoresis microchip with integrated pencil-drawn electrodes for contactless conductivity detection|
|Author:||Chagas, Cyro L. S.|
Souza, Fabrício R. de
Cardoso, Thiago M. G.
Moreira, Roger C.
Silva, José A. F. da
Jesus, Dosil P. de
Coltro, Wendell K. T.
|Abstract:||We describe for the first time the fabrication of a paper-based microchip electrophoresis (pME) device with integrated hand-drawn pencil electrodes to perform capacitively coupled contactless conductivity detection (C4D). This low-cost device (less than $0.10) revealed great capability to dissipate heat, good injection-to-injection repeatability, and ease of attaching pencil-drawn electrodes on the separation channel. The feasibility of the proposed pME-C4D device was successfully demonstrated with the separation of bovine serum albumin and creatinine within 150 s with baseline resolution. The limits of detection values for albumin and creatinine were 20 and 35 μmol L−1, respectively. These biomolecules present clinical relevance as evidence of kidney failure. The proposed pME-C4D offers great potential to be explored in the diagnosis of diabetes mellitus and heart disease|
|Editor:||Royal Society of Chemistry|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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