Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354559
Type: Artigo
Title: Von willebrand factor, adamts13 and d-dimer are correlated with different levels of nephropathy in type 1 diabetes mellitus
Author: Domingueti, Caroline Pereira
Dusse, Luci Maria S.
Fóscolo, Rodrigo Bastos
Reis, Janice Sepúlveda
Annichino-Bizzacchi, Joyce Maria
Orsi, Fernanda Loureiro de Andrade
Mazetto, Bruna de Moraes
Carvalho, Maria das Graças
Gomes, Karina Braga
Fernandes, Ana Paula
Abstract: We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal function through estimated glomerular filtration rate: ≥90 and <130mL/min/1,73m2, n=52 (control group), ≥60 and <90mL/min/1,73m2, n=29 (mild renal dysfunction group), <60mL/min/1,73m2, n=28 (severe renal dysfunction group); and through urinary albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria. Von Willebrand factor, ADAMTS13, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay. ADAMTS13 activity was determined by fluorescence resonance energy transfer assay. Von Willebrand factor levels were increased in patients with mild (P=0.001) and severe (P<0.001) renal dysfunction as compared to the control group. ADAMTS13 levels were also increased in mild (P=0.029) and severe (P=0.002) renal dysfunction groups in comparison to the control group, while ADAMTS13 activity was increased only in the severe renal dysfunction group as compared to the control group (P=0.006). No significant differences were observed among the groups regarding von Willebrand factor/ADAMTS13 ratio. ADAMTS13 activity/ADAMTS13 levels ratio was reduced in patients with mild (P=0.013) and severe (P=0.015) renal dysfunction as compared to the control group. D-Dimer levels were increased in patients with mild (P=0.006) and severe (P<0.001) renal dysfunction as compared to the control group; it was also higher in patients with severe renal dysfunction as compared to the mild renal dysfunction group (P=0.019). Similar results were found for albuminuria classification. Increased von Willebrand factor, ADAMTS13, and D-Dimer levels and decreased ADAMTS13 activity/ADAMTS13 levels ratio are associated with renal dysfunction in patients with type 1 diabetes, suggesting that endothelial dysfunction and hypercoagulability are associated with nephropathy in type 1 diabetes
Subject: Nefropatias
Country: Estados Unidos
Editor: Public Library of Science
Rights: Fechado
Identifier DOI: 10.1371/journal.pone.0132784
Address: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132784
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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