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Type: Artigo
Title: Ancient DNA sequence revealed by error-correcting codes
Author: Brandão, Marcelo M.
Spoladore, Larissa
Faria, Luzinete C. B.
Rocha, Andréa S. L.
Silva-Filho, Marcio C.
Palazzo, Reginaldo
Abstract: A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code
Subject: DNA
Country: Reino Unido
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1038/srep12051
Date Issue: 2015
Appears in Collections:FEEC - Artigos e Outros Documentos
CBMEG - Artigos e Outros Documentos

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