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http://repositorio.unicamp.br/jspui/handle/REPOSIP/354557
Type: | Artigo |
Title: | Ancient DNA sequence revealed by error-correcting codes |
Author: | Brandão, Marcelo M. Spoladore, Larissa Faria, Luzinete C. B. Rocha, Andréa S. L. Silva-Filho, Marcio C. Palazzo, Reginaldo |
Abstract: | A previously described DNA sequence generator algorithm (DNA-SGA) using error-correcting codes has been employed as a computational tool to address the evolutionary pathway of the genetic code. The code-generated sequence alignment demonstrated that a residue mutation revealed by the code can be found in the same position in sequences of distantly related taxa. Furthermore, the code-generated sequences do not promote amino acid changes in the deviant genomes through codon reassignment. A Bayesian evolutionary analysis of both code-generated and homologous sequences of the Arabidopsis thaliana malate dehydrogenase gene indicates an approximately 1 MYA divergence time from the MDH code-generated sequence node to its paralogous sequences. The DNA-SGA helps to determine the plesiomorphic state of DNA sequences because a single nucleotide alteration often occurs in distantly related taxa and can be found in the alternative codon patterns of noncanonical genetic codes. As a consequence, the algorithm may reveal an earlier stage of the evolution of the standard code |
Subject: | DNA |
Country: | Reino Unido |
Editor: | Springer |
Rights: | Aberto |
Identifier DOI: | 10.1038/srep12051 |
Address: | https://www.nature.com/articles/srep12051 |
Date Issue: | 2015 |
Appears in Collections: | FEEC - Artigos e Outros Documentos CBMEG - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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000357715500001.pdf | 2.07 MB | Adobe PDF | View/Open |
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