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Type: Artigo
Title: Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis
Author: Pinto, Silas
Sato, Vitor N.
De-Souza, Evandro A.
Ferraz, Rafael C.
Camara, Henrique
Pinca, Ana Paula F.
Mazzotti, Diego R.
Lovci, Michael T.
Tonon, Guilherme
Lopes-Ramos, Camila M.
Parmigiani, Raphael B.
Wurtele, Martin
Massirer, K
Abstract: Alterations in microRNA (miRNA) processing have been previously linked to aging. Here we used the small molecule enoxacin to pharmacologically interfere with miRNA biogenesis and study how it affects aging in C. elegans. Enoxacin extended worm lifespan an
Subject: Enoxacino
Caenorhabditis elegans
Adenosina desaminase
Proteínas de ligação a RNA
Caenorhabditis elegans
Adenosine deaminase
RNA-binding proteins
Country: Países baixos
Editor: Elsevier
Rights: aberto
Identifier DOI: 10.1016/j.redox.2018.06.006
Date Issue: 2018
Appears in Collections:IB - Artigos e Outros Documentos

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