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Type: Artigo
Title: Dimethyl fumarate downregulates the immune response through the HCA(2)/GPR109A pathway: Implications for the treatment of multiple sclerosis
Author: Von Glehn, Felipe
, Dias-Carneiro, Rafael P. C.
Moraes, Adriel S.
Farias, Alessandro S.
Silva, Veronica A. P. G.
Oliveira, Francisco T. M.
Silva, Carlos Eduardo B. G.
Carvalho, Fabricio de
Rahal, Elaine
Baecher-Allan, Clare
Santos, Leon
Abstract: The mechanisms of action of dimethyl fumarate (DMF), and its metabolite, monomethyl fumarate (MMF), for the treatment of multiple sclerosis are not completely elucidated. To discuss the role of DMF/MMF-induced hydroxycarboxylic acid receptor 2 (HCA2/GPR10
Subject: Esclerose múltipla
Fumarato de dimetilo
Receptores acoplados a proteínas-G
Multiple sclerosis
Dimethyl fumarate
Immunosuppressive agents
Receptors, G-protein-coupled
Country: Países Baixos
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.msard.2018.04.016
Date Issue: 2018
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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