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Type: Artigo
Title: A novel dosage form for buccal administration of bupropion
Author: Almeida, Nilsa Maria Galvão
Lima, Renata
Alves, Thaís Francine Ribeiro
Rebelo, Márcia de Araújo
Severino, Patrícia
Chaud, Marco Vinícius
Abstract: Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm2. The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking
Subject: Hábito de fumar
Country: Brasil
Editor: USP/Faculdade de Ciências Farmacêuticas
Rights: Aberto
Identifier DOI: 10.1590/S1984-82502015000100010
Date Issue: 2015
Appears in Collections:FEQ - Artigos e Outros Documentos

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