Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354362
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSaad, Sara Teresinha Olalla-
dc.contributor.authorunicampMetze, Konradin-
dc.contributor.authorunicampLorand-Metze, Irene-
dc.typeArtigopt_BR
dc.titleA simple score derived from bone marrow immunophenotyping is important for prognostic evaluation in myelodysplastic syndromespt_BR
dc.contributor.authorVido‑Marques, J. R.-
dc.contributor.authorReis‑Alves, S. C.-
dc.contributor.authorSaad, S.T. O.-
dc.contributor.authorMetze, K.-
dc.contributor.authorLorand‑Metze, I.-
dc.subjectMedula ósseapt_BR
dc.subject.otherlanguageBone marrowpt_BR
dc.description.abstractImmunophenotyping of bone marrow (BM) precursors has been used as an ancillary diagnostic tool in myelodysplastic syndromes (MDS), but there is no general agreement about which variables are the most relevant for prognosis. We developed a parsimonious prognostic model based on BM cell populations well-defined by phenotype. We analyzed 95 consecutive patients with primary MDS diagnosed at our Institution between 2005 and 2012 where BM immunophenotyping had been performed at diagnosis. Median follow-up: 42 months (4–199). Median age: 67 years (33–79). According to IPSS-R, 71 cases were low or intermediate risk. Flow variables significant in the univariate Cox analysis: “%monocytes/TNCs”, “% CD16+ monocytes/TNCs”, “total alterations in monocytes”, “% myeloid CD34+ cells”, “number of abnormal expressions in myeloblasts” and “% of B-cell progenitors”. In the multivariate model remained independent: “% myeloid CD34+ cells”, B-cell progenitors” and “% CD16+ monocytes/TNCs”. These variables were categorized by the extreme quartile risk ratio strategy in order to build the score: % myeloid CD34+ cells” (≥ 2.0% = 1 point), B-cell progenitors” (< 0.05% 1 point) and “CD16+ monocytes/TNCs” (≥ 1.0% 1 point). This score could separate patients with a different survival. There was a weak correlation between the score and IPSS-R. Both had independent prognostic values and so, the flow score adds value for the prognostic evaluation in MDSpt_BR
dc.relation.ispartofScientific reportspt_BR
dc.relation.ispartofabbreviationSci. rep.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherSpringerpt_BR
dc.date.issued2020-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn2045-2322pt_BR
dc.identifier.doi10.1038/s41598-020-77158-zpt_BR
dc.identifier.urlhttps://www.nature.com/articles/s41598-020-77158-zpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber305110/2018-7; 309910/2018-8pt_BR
dc.date.available2021-01-20T16:50:00Z-
dc.date.accessioned2021-01-20T16:50:00Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-01-20T16:50:00Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2021-01-20T16:50:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354362-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000594658100002pt_BR
dc.creator.orcid0000-0003-0809-8068pt_BR
dc.creator.orcid0000-0003-0742-8846pt_BR
dc.creator.orcid0000-0002-6516-1265pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid20281pt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000594658100002.pdf1.15 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.