Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354214
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGodoy, Helena Teixeira-
dc.contributor.authorunicampCosta, Yanna Dias-
dc.contributor.authorunicampMazzafera, Paulo-
dc.typeArtigopt_BR
dc.titleUnraveling the biosynthesis of pilocarpine in pilocarpus microphylluspt_BR
dc.contributor.authorSawaya, Alexandra Christine Helena Frankland-
dc.contributor.authorCosta, Yanna Dias-
dc.contributor.authorMazzafera, Paulo-
dc.subjectAlcaloidespt_BR
dc.subject.otherlanguageAlkaloidspt_BR
dc.description.abstractPilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids related to pilocarpine have been reported in the previous years, little is still known about its biosynthetic route. At most, histidine has been reported as the precursor of pilocarpine. Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllophiline and anhydropilosine) were supplied to P. microphyllus leaves and the alkaloid profile analyzed by UPLC-MS, we suggest a biosynthesis pathway for pilocarpine. Further experiments using labeled precursors associated with transcriptome data may allow us to understand the whole biosynthesis pathway and its genetic controlpt_BR
dc.relation.ispartofNatural product communicationspt_BR
dc.relation.ispartofabbreviationNat. prod. commun.pt_BR
dc.publisher.cityReino Unidopt_BR
dc.publisher.countryLondrespt_BR
dc.publisherSage Publicationspt_BR
dc.date.issued2015-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage721pt_BR
dc.description.lastpage724pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1934-578Xpt_BR
dc.identifier.eissn1555-9475pt_BR
dc.identifier.doi10.1177/1934578X1501000506pt_BR
dc.identifier.urlhttps://journals.sagepub.com/doi/abs/10.1177/1934578X1501000506pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumber2009/00773-4pt_BR
dc.date.available2021-01-19T13:47:22Z-
dc.date.accessioned2021-01-19T13:47:22Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-01-19T13:47:22Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-03-08T18:36:57Z : No. of bitstreams: 1 000354668100008.pdf: 380724 bytes, checksum: 496efecd26a36b41b9932b38d184b4de (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-19T13:47:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354214-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Vegetalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.subject.keywordImidazole alkaloidspt_BR
dc.subject.keywordJaborandipt_BR
dc.subject.keywordPilosinept_BR
dc.subject.keywordAnhydropilosinept_BR
dc.subject.keywordTrachyllophilinept_BR
dc.identifier.source000354668100008pt_BR
dc.creator.orcid0000-0001-7524-6628pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-9073-4056pt_BR
dc.type.formArtigopt_BR
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