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Type: Artigo
Title: Unraveling the biosynthesis of pilocarpine in pilocarpus microphyllus
Author: Sawaya, Alexandra Christine Helena Frankland
Costa, Yanna Dias
Mazzafera, Paulo
Abstract: Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. Pilocarpine has several important pharmaceutical applications. Although several imidazole alkaloids related to pilocarpine have been reported in the previous years, little is still known about its biosynthetic route. At most, histidine has been reported as the precursor of pilocarpine. Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllophiline and anhydropilosine) were supplied to P. microphyllus leaves and the alkaloid profile analyzed by UPLC-MS, we suggest a biosynthesis pathway for pilocarpine. Further experiments using labeled precursors associated with transcriptome data may allow us to understand the whole biosynthesis pathway and its genetic control
Subject: Alcaloides
Country: Londres
Editor: Sage Publications
Rights: Fechado
Identifier DOI: 10.1177/1934578X1501000506
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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