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Type: Artigo
Title: Immunoprofile of C-MET/PI3k signaling in human salivary gland tumors
Author: Vasconcelos, Artur Cunha
Wagner, Vivian Petersen
Meurer, Luise
Vargas, Pablo Agustin
de Souza, Lelia Batista
Fonseca, Felipe Paiva
Squarize, Cristiane Helena
Castilho, Rogerio Moraes
Martins, Manoela Domingues
Abstract: The aim of this study was to analyze the expression pattern of proteins in the HGF/c-MET/PI3K signaling pathway in salivary gland tumors (SGTs) and to correlate the findings with the proliferative index and clinical parameters. We assembled tissue microarrays (TMAs) of 108 cases of SGTs, including 69 cases of pleomorphic adenoma (PA), 24 cases of adenoid cystic carcinoma (AdCC), and 15 cases of mucoepidermoid carcinoma (MEC). An immunohistochemical analysis of hepatocyte growth factor (HGF), MET phosphorylation (p-MET), protein kinase B (AKT) phosphorylation (p-AKT), and Ki-67 proteins was performed. Benign and malignant SGTs presented similar scores of HGF-positive cells (P = .36), whereas, malignant SGTs exhibited higher levels of p-MET (P = .001) and p-AKT (P = .001) than benign SGTs. No correlation of HGF, p-MET, or p-AKT expression was observed with clinical parameters. PA had a lower proliferative index than either AdCC (P = .001) or MEC (P = .001). The salivary gland carcinomas exhibited increased activation of the HGF pathway, as evidenced by the phosphorylation of the MET receptor, and increased activation of the PI3K pathway, as indicated by p-AKT. These data suggest that the HGF/c-MET/PI3K signaling pathway is active in SGTs, especially in malignant neoplasms
Subject: Fator de crescimento de hepatócito
Carcinoma adenoide cístico
Carcinoma de células escamosas
Proteínas tirosina quinases
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.oooo.2015.04.003
Date Issue: 2015
Appears in Collections:FOP - Artigos e Outros Documentos

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