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|Title:||Stereoselective synthesis of 3-hydroxy-4-arylcyclopentanones and 4-arylcyclopentenones through a heck-matsuda desymmetrization of meso Cis-4-cyclopentene-1,3-diol|
|Author:||Carmona, Rafaela C.|
Correia, Carlos Roque D.
|Abstract:||A new palladium-catalyzed route to 3-hydroxy-4-arylcyclopentanones and 4-arylcyclopentenones in a diastereo- and enantioselective manner by a Heck-Matsuda desymmetrization was achieved from the commercially available meso cis-4-cyclopentene-1,3-diol. This method is highly practical, mild, high yielding and is carried out under "open vessel" conditions. Protected and unprotected substrates provide distinct products bearing considerable value as synthetic scaffolds for the synthesis of natural and unnatural bioactive compounds containing a five-membered ring|
Heck-Matsuda, reação de
|Editor:||John Wiley & Sons|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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