Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/354115
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOliveira, Rosimeire Nunes de-
dc.contributor.authorunicampAllegretti, Silmara Marques-
dc.typeArtigopt_BR
dc.titleAnthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of schistosoma mansonipt_BR
dc.contributor.authorGuimarães, Maria A.-
dc.contributor.authorOliveira, Rosimeire N. de-
dc.contributor.authorVéras, Leiz M. C.-
dc.contributor.authorLima, David F.-
dc.contributor.authorCampelo, Yuri D. M.-
dc.contributor.authorCampos, Stefano Augusto-
dc.contributor.authorKuckelhaus, Selma A. S.-
dc.contributor.authorPinto, Pedro L. S.-
dc.contributor.authorEaton, Peter-
dc.contributor.authorMafud, Ana C.-
dc.contributor.authorMascarenhas, Yvonne P.-
dc.contributor.authorAllegretti, Silmara M.-
dc.contributor.authorMoraes, Josué de-
dc.contributor.authorLolić, Aleksandar-
dc.contributor.authorVerbić, Tatjana-
dc.contributor.authorLeite, José Roberto S. A.-
dc.subjectSchistosoma mansonipt_BR
dc.subject.otherlanguageSchistosoma mansonipt_BR
dc.description.abstractSchistosomiasis is a serious disease currently estimated to affect more that 207 million people worldwide. Due to the intensive use of praziquantel, there is increasing concern about the development of drug-resistant strains. Therefore, it is necessary to search for and investigate new potential schistosomicidal compounds. This work reports the in vivo effect of the alkaloid epiisopiloturine (EPI) against adults and juvenile worms of Schistosoma mansoni. EPI was first purified its thermal behavior and theoretical solubility parameters charaterised. In the experiment, mice were treated with EPI over the 21 days post-infection with the doses of 40 and 200 mg/kg, and 45 days post-infection with single doses of 40, 100 and 300 mg/kg. The treatment with EPI at 40 mg/kg was more effective in adult worms when compared with doses of 100 and 300 mg/kg. The treatment with 40 mg/kg in adult worms reduced parasite burden significantly, lead to reduction in hepatosplenomegaly, reduced the egg burden in faeces, and decreased granuloma diameter. Scanning electron microscopy revealed morphological changes to the parasite tegument after treatment, including the loss of important features. Additionally, the in vivo treatment against juvenile with 40 mg/kg showed a reduction of the total worm burden of 50.2%. Histopathological studies were performed on liver, spleen, lung, kidney and brain and EPI was shown to have a DL50 of 8000 mg/kg. Therefore EPI shows potential to be used in schistosomiasis treatment. This is the first time that schistosomicidal in vivo activity of EPI has been reportedpt_BR
dc.relation.ispartofPLoS neglected tropical diseasespt_BR
dc.relation.ispartofabbreviationPLoS neglect trop dispt_BR
dc.publisher.citySan Francisco, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherPublic Library of Sciencept_BR
dc.date.issued2015-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage1pt_BR
dc.description.lastpage18pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1935-2727pt_BR
dc.identifier.eissn1935-2735pt_BR
dc.identifier.doi10.1371/journal.pntd.0003656pt_BR
dc.identifier.urlhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003656pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber490585/2010- 8; 40/2012; 404134/2012-2pt_BR
dc.description.sponsordocumentnumber705/2009pt_BR
dc.description.sponsordocumentnumber2014/02282-6pt_BR
dc.date.available2021-01-18T12:43:36Z-
dc.date.accessioned2021-01-18T12:43:36Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2021-01-18T12:43:36Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-03-08T18:36:54Z : No. of bitstreams: 1 000352199400102.pdf: 2336726 bytes, checksum: 0fde378f055082b2b5db3e2efd5143dc (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-18T12:43:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/354115-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Animalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source000352199400102pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4975-3663pt_BR
dc.type.formArtigo de pesquisapt_BR
dc.identifier.articleide0003656pt_BR
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