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Type: Artigo
Title: Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella Flexneri
Author: Connor, Thomas R.
Barker, Clare R.
Baker, Kate S.
Weill, Francois-Xavier
Talukder, Kaisar Ali
Smith, Anthony M.
Stephen Baker
Gouali, Malika
Duy Pham Thanh
Azmi, Ishrat Jahan
da Silveira, Wanderley Dias
Semmler, Torsten
Wieler, Lothar H.
Jenkins, Claire
Cravioto, Alejandro
Abstract: Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the S. flexneri PGs we identify geographically restricted sub-lineages that appear to have persistently colonised regions for many decades to over 100 years. Although we found abundant evidence of antimicrobial resistance (AMR) determinant acquisition, our dataset shows no evidence of subsequent intercontinental spread of antimicrobial resistant strains. The pattern of colonisation and AMR gene acquisition suggest that S. flexneri has a distinct life-cycle involving local persistence. DOI: 10.7554/eLife.07335.001
Subject: Salmonella typhimurium
Escherichia coli
Country: Reino Unido
Editor: eLife Sciences Publications
Rights: Aberto
Identifier DOI: 10.7554/eLife.07335
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos

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