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Type: Artigo
Title: Gut bacteria products prevent Aki induced by ischemia-reperfusion
Author: Andrade-Oliveira, Vinicius
Amano, Mariane T.
Correa-Costa, Matheus
Castoldi, Angela
Felizardo, Raphael J. F.
de Almeida, Danilo C.
Bassi, Enio J.
Moraes-Vieira, Pedro M.
Hiyane, Meire I.
Rodas, Andrea C. D.
Peron, Jean P. S.
Aguiar, Cristhiane F.
Reis, Marlene A.
Ribeiro, Willian R.
Valduga, Claudete J.
Curi, Rui
Ramirez Vinolo, Marco Aurelio
Ferreira, Caroline M.
Saraiva Camara, Niels Olsen
Abstract: Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal nnicrobiota and have anti-inflammatory and histone deacetylase inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondria! biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification
Subject: Ácidos graxos de cadeia curta
Células dendríticas
Lesão renal aguda
Country: Estados Unidos
Editor: American Society of Nephrology
Rights: Fechado
Identifier DOI: 10.1681/ASN.2014030288
Date Issue: 2015
Appears in Collections:IB - Artigos e Outros Documentos

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