Please use this identifier to cite or link to this item:
Type: Artigo
Title: Android fat distribution affects some hemostatic parameters in women with polycystic ovary syndrome compared with healthy control subjects matched for age and body mass index
Author: Marques Furtado de Mendonca-Louzeiro, Maria Raquel
Annichino-Bizzacchi, Joyce Maria
Benetti-Pinto, Cristina Laguna
Abstract: To correlate hemostatic parameters with clinical markers of fat distribution and laboratory variables in women with polycystic ovary syndrome (PCOS) compared with healthy control subjects.Cross-sectional study. Tertiary teaching hospital. Forty-five women with PCOS and 45 control women matched for age and body mass index (BMI). Clinical evaluation and venipuncture. Age, BMI, waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), Ferriman-Gallwey index, fasting glucose, fasting insulin, total testosterone, free testosterone (FT), thrombin-activatable fibrinolysis inhibitor (TAFI), D-dimer, plasminogen activator inhibitor (PAI) 1, and the parameters of thrombin generation test (TGT), including the lag time (Tlag), time to peak thrombin generation (Tmax), peak concentration (Cmax), and the area under the thrombin generation curve (TAUC). In the PCOS group, BMI and WC correlated positively with TAFI, D-dimer, PAI-1, Cmax, and TAUC; HC with D-dimer and PAI-1; WHR with TAFI, D-dimer, and PAI-1; glucose with TAFI; insulin and homeostasis-model assessment of insulin resistance with PAI-1; and FT with Cmax and TAUC. Age correlated positively with D-dimer and PAI-1, and negatively with Tlag and Tmax. In the control group, there were no correlations between clinical markers of fat distribution and hemostatic parameters, but age and fasting glucose correlated positively with PAI-1, and FT with Tmax and TAUC. In PCOS, android body fat distribution may directly affect hemostatic parameters, particularly in young and overweight women. Further studies are needed to establish a correlation between these results and an increase in thromboembolic risk. (C) 2015 by American Society for Reproductive Medicine
Subject: Síndrome do ovário policístico
Trombose venosa
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.fertnstert.2015.05.013
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.