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Type: Artigo
Title: Hypothalamic energy metabolism is impaired by doxorubicin independently of inflammation in non‐tumour‐bearing rats
Author: Antunes, Barbara M. M.
Lira, Fabio Santos
Pimentel, Gustavo Duarte
Rosa Neto, José Cesar
Esteves, Andrea Maculano
Oyama, Lila Missae
Souza, Cláudio Teodoro de
Gonçalves, Cinara Ludvig
Streck, Emilio Luiz
Rodrigues, Bruno
Santos, Ronaldo Vagner dos
Mello, Marco Túlio de
Abstract: We sought to explore the effects of doxorubicin on inflammatory profiles and energy metabolism in the hypothalamus of rats. To investigate these effects, we formed two groups: a control (C) group and a Doxorubicin (DOXO) group. Sixteen rats were randomly assigned to either the control (C) or DOXO groups. The hypothalamus was collected. The levels of interleukin (IL)‐1β, IL‐6, IL‐10, TNF‐α and energy metabolism (malate dehydrogenase, complex I and III activities) were analysed in the hypothalamus. The DOXO group exhibited a decreased body weight (p < 0.01). Hypothalamic malate dehydrogenase activity was reduced when compared with control (p < 0.05). In addition, pro‐inflammatory cytokine levels were unchanged. Therefore, our results demonstrate that doxorubicin leads to an impairment of \hypothalamic energy metabolism, but do not affect the inflammatory pathway.
Subject: Doxorrubicina
Metabolismo energético
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/cbf.3127
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos
FEF - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos

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