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Type: Artigo
Title: Biopharmaceuticals from microorganisms: from production to purification
Author: Jozala, Angela Faustino
Geraldes, Danilo Costa
Tundisi, Louise Lacalendola
Feitosa, Valker de Araújo
Breyer, Carlos Alexandre
Cardoso, Samuel Leite
Mazzola, Priscila Gava
Oliveira-Nascimento, Laura de
Rangel-Yagui, Carlota de Oliveira
Magalhães, Pérola de Oliveira
Oliveira, Marcos Antonio de
Pessoa Jr, Adalberto
Abstract: The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.
Subject: Fermentação
Country: Brasil
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1016/j.bjm.2016.10.007
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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