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Type: Artigo
Title: Do genetic polymorphisms modulate response rate and toxicity of cisplatin associated with radiotherapy in Laryngeal Squamous cell carcinoma? A case report
Author: Lopes-Aguiar, Leisa
Visacri, Marilia Berlofa
Lopes Nourani, Carolina Marques
Dias Costa, Ericka Francislaine
Silva Nogueira, Guilherme Augusto
Penna Lima, Tathiane Regine
Pincinato, Eder Carvalho
Moriel, Patricia
Carrasco Altemani, Joao Mauricio
Passos Lima, Carmen Silvia
Abstract: Cisplatin (CDDP) plus radiotherapy (RT) has been used to treat advanced laryngeal squamous cell carcinoma (LSCC) patients. Single nucleotide polymorphisms (SNPs) may be responsible for differences in chemo/radiosensitivity and side effects in those patients. We reported an advanced LSCC patient, who obtained durable complete response and unexpected pronounced toxicity during CDDP and RT, possibly due to SNPs in genes that modulate the effects of this therapeutic modality. Case presentation: A 30-year-old man with advanced LSCC obtained durable complete response and severe alopecia and pancytopenia after standard and reduced doses of CDDP and RT. Analyses of SNPs revealed that the patient presented GSTT1 deletion, variant MSH3 1045ThrThr, wild GSTP1 105IleIle, and wild BAX -248GG genotypes, which were previously described in association with abnormal detoxification, DNA repair, and damaged cell apoptosis, respectively. Seven other advanced LSCC patients with GSTT1 gene, MSH3 AlaAla or AlaThr, GSTP1 IleVal or ValVal, and BAX GA or AA genotypes served as controls of the study. Only 1 control presented complete response; the other 6 controls obtained partial response of short duration. Four and 3 controls presented grade 1 or 2 and grade 3 anemia or leukopenia during treatment, respectively. The CDDP level in urine collected after CDDP infusion in the reported patient was lower than the median value obtained in controls, suggesting a higher amount of intracellular CDDP in the reported case
Subject: Polimorfismo de nucleotídeo único
Country: Estados Unidos
Editor: Lippincott Williams & Wilkins
Rights: Fechado
Identifier DOI: 10.1097/MD.0000000000000578
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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