Please use this identifier to cite or link to this item:
Type: Artigo
Title: Acute sildenafil use reduces 24‐hour blood pressure levels in patients with resistant hypertension: a placebo‐controlled, crossover trial
Author: Catharina, Arthur Santa
Modolo, Rodrigo
Ritter, Alessandra Mileni Versuti
Quinaglia, Thiago
Amorim, Rivadavio Fernandes Batista de
Moreno, Heitor
Faria, Ana Paula de
Abstract: The authors previously demonstrated that acute administration of sildenafil—a phosphodiesterase 5 (PDE5) inhibitor—improves hemodynamic parameters in patients with resistant hypertensive (RH), but its effect on ambulatory blood pressure monitoring (ABPM) is unknown. This interventional, nonrandomized, single‐blinded, placebo‐controlled, crossover trial included 26 patients with RH. A dose of sildenafil (187.5mg) was given, and after a washout period of 14 days the patients received a single oral dose of placebo and the protocol was repeated. The patients underwent 24‐hour ABPM recordings the day before and immediately after the protocols. The reduction of systolic (−8.8±1.4 vs 1.3±1.2 mm Hg, P=.02), diastolic (−5.3±3.3 vs 1.8±1.1 mm Hg, P=.03), and mean (−7.9±3.6 vs 0.8±0.9 mm Hg, P=.01) 24‐hour BP were found after the use of sildenafil compared with placebo. Improvement in daytime BP levels was also observed (systolic −6.0±4.7 vs 4.4±1.5 mm Hg [P=.02] and mean −4.8±3.9 vs 3.5±1.4 mm Hg [P=.02] for sildenafil vs placebo, respectively). Considering its antihypertensive effect, sildenafil may represent a therapeutic option for RH treatment
Subject: Hipertensão
Country: Estados Unidos
Editor: Le Jacq Communications
Rights: Fechado
Identifier DOI: 10.1111/jch.12850
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos
HC - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000387336500015.pdf293.24 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.