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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPalei, Ana Carolina Taveiros-
dc.typeArtigopt_BR
dc.titleAntihypertensive therapy in preeclampsia is not modulated by VEGF polymorphismspt_BR
dc.contributor.authorSandrim, Valeria C.-
dc.contributor.authorPalei, Ana C. T.-
dc.contributor.authorNibia, Eleuterio-
dc.contributor.authorTanus-Santos, José E.-
dc.contributor.authorCavalli, Ricardo C.-
dc.subjectPre-eclâmpsiapt_BR
dc.subjectPolimorfismo (Genética)pt_BR
dc.subject.otherlanguagePre-Eclampsiapt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.description.abstractVascular endothelial growth factor (VEGF) is relevant for healthy pregnancy, and abnormalities in VEGF functions have been associated with hypertensive disorders of pregnancy. Our group recently demonstrated that VEGF genetic polymorphisms affect the susceptibility to preeclampsia (PE). Therefore, in this study our aim is to examine whether VEGF polymorphisms affect the antihypertensive responses in women with PE. We studied 113 white PE women who were stratified according to blood pressure levels after antihypertensive treatment (46 responsive, R group and 67 non-responsive, NR group). We then compared the frequencies of two VEGF genetic polymorphisms (C-2578A and G-634C) between R and NR groups. We found no significant differences in genotype or allele distributions between R and NR groups (P > 0.05). In addition, no difference was observed in overall distribution of haplotypes (P > 0.05). Our data suggest that VEGF polymorphisms do not affect responsiveness to the antihypertensive therapy in PE.pt_BR
dc.relation.ispartofArchives of gynecology and obstetricspt_BR
dc.relation.ispartofabbreviationArch. gynecol. obstet.pt_BR
dc.publisher.cityHeidelbergpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherSpringerpt_BR
dc.date.issued2015-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume291pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage799pt_BR
dc.description.lastpage803pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0932-0067pt_BR
dc.identifier.eissn1432-0711pt_BR
dc.identifier.doi10.1007/s00404-014-3475-2pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007/s00404-014-3475-2pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-01-07T11:21:19Z-
dc.date.accessioned2021-01-07T11:21:19Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-01-07T11:21:19Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:02:28Z : No. of bitstreams: 1 000351152400017.pdf: 252382 bytes, checksum: d4cc23bd423419db435d43c978cf4a96 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-07T11:21:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353747-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordVEGFpt_BR
dc.identifier.source000351152400017pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigopt_BR
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