Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353735
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRodrigues, Bárbara de Almeida-
dc.contributor.authorunicampPauli, Luciana Santos Souza-
dc.contributor.authorunicampCintra, Dennys Esper-
dc.contributor.authorunicampChiarreotto-Ropelle, Eloize Cristina-
dc.contributor.authorunicampBotezelli, José Diego-
dc.contributor.authorunicampRopelle, Eduardo Rochete-
dc.contributor.authorunicampPauli, José Rodrigo-
dc.typeArtigopt_BR
dc.titleAcute exercise decreases tribbles homolog 3 protein levels in the hypothalamus of obese ratspt_BR
dc.contributor.authorRodrigues, Bárbara de Almeira-
dc.contributor.authorPauli, Luciana Santos Souza-
dc.contributor.authorDe Souza, Claudio Teodoro-
dc.contributor.authorDa Silva, Adelino Sanchez Ramos-
dc.contributor.authorCintra, Dennys Eesper Correa-
dc.contributor.authorMarinho, Rodolfo-
dc.contributor.authorDe Moura, Leandro Pereira-
dc.contributor.authorRopelle, Eloize Cristina Chiarreotto-
dc.contributor.authorBotezelli, José Diego-
dc.contributor.authorRopelle, Eduardo Rochete-
dc.contributor.authorPauli, José Rodrigo-
dc.subjectObesidadept_BR
dc.subject.otherlanguageObesitypt_BR
dc.description.abstractThis study aims to evaluate the effects of acute exercise on tribbles homolog 3 (TRB3) protein levels and on the interaction between TRB3 and Akt proteins in the hypothalamus of obese rats. In addition, we evaluated the relationship between TRB3 and endoplasmic reticulum (ER) stress and verified whether an acute exercise session influences them. In the first part of the study, the rats were divided into three groups: control (lean), fed standard rodent chow; DIO, fed a high-fat diet; and DIO-EXE, fed a high-fat diet and submitted to a swimming acute exercise protocol. In the second part of the study, we used three other groups: control (lean) group receiving an intracerebroventricular (i.c.v.) infusion of vehicle, lean group receiving an i.c.v. infusion of thapsigargin, and lean group receiving an i.c.v. infusion of thapsigargin and performing an acute exercise session. Four hours after the exercise session, food intake was measured, and the hypothalamus was dissected and separated for subsequent protein analysis by immunoblotting and real-time polymerase chain reaction. The acute exercise session reduced TRB3 protein levels, disrupted the interaction between TRB3 and Akt proteins, increased the phosphorylation of Foxo1, and restored the anorexigenic effects of insulin on the hypothalamus of DIO rats. Interestingly, the suppressive effects of acute exercise on TRB3 protein levels may be related, at least in part, to decreased ER stress (evaluated though pancreatic ER kinase phosphorylation and C/EBP homologous protein levels) in the hypothalamus. Exercise-mediated reduction of hypothalamic TRB3 protein levels may be associated with reduction of ER stress. These data provide a new mechanism by which an acute exercise session improves insulin sensitivity in the hypothalamus and restores food intake control in obesity.pt_BR
dc.relation.ispartofMedicine and science in sports and exercisept_BR
dc.relation.ispartofabbreviationMed. sci. sports exerc.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherLippincott Williams and Wilkinspt_BR
dc.date.issued2015-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume47pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage1613pt_BR
dc.description.lastpage1623pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0195-9131pt_BR
dc.identifier.eissn1530-0315pt_BR
dc.identifier.doi10.1249/MSS.0000000000000585pt_BR
dc.identifier.urlhttps://journals.lww.com/acsm-msse/Fulltext/2015/08000/Acute_Exercise_Decreases_Tribbles_Homolog_3.8.aspxpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber471498/2011-4pt_BR
dc.description.sponsordocumentnumber2013/21491-2; 2013/25512-4pt_BR
dc.date.available2021-01-06T15:53:32Z-
dc.date.accessioned2021-01-06T15:53:32Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-01-06T15:53:31Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:01:49Z : No. of bitstreams: 1 000357942200008.pdf: 1885467 bytes, checksum: e87ca667d8ad984989d58c831ac7eb75 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-06T15:53:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353735-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.subject.keywordEndoplasmic-reticulum stresspt_BR
dc.subject.keywordImproves insulinpt_BR
dc.subject.keywordGlucose-homeostasispt_BR
dc.subject.keywordEndurance exercisept_BR
dc.subject.keywordCell-deathpt_BR
dc.subject.keywordInduced insulin-resistancept_BR
dc.subject.keywordWistar ratspt_BR
dc.subject.keywordSkeletal-musclept_BR
dc.subject.keywordTrb3 expressionpt_BR
dc.subject.keywordDiabetic micept_BR
dc.identifier.source000357942200008pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-7954-5630pt_BR
dc.creator.orcid0000-0003-1655-9557pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-1655-9557pt_BR
dc.creator.orcid0000-0002-6129-1521pt_BR
dc.type.formArtigopt_BR
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