Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353722
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGomes, Valeria Aguiar-
dc.typeArtigopt_BR
dc.titleReduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosispt_BR
dc.contributor.authorRocha, M.G.-
dc.contributor.authorGomes, V.A.-
dc.contributor.authorTanus-Santos, J.E.-
dc.contributor.authorRosa-e-Silva, J.C.-
dc.contributor.authorCandido-dos-Reis, F.J.-
dc.contributor.authorNogueira, A.A.-
dc.contributor.authorPoli-Neto, O.B.-
dc.subjectEndometriosept_BR
dc.subjectÓxido nítricopt_BR
dc.subject.otherlanguageEndometriosispt_BR
dc.subject.otherlanguageNitric oxidept_BR
dc.description.abstractThe objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization.pt_BR
dc.relation.ispartofBrazilian journal of medical and biological researchpt_BR
dc.relation.ispartofabbreviationBraz. j. med. biol. res.pt_BR
dc.publisher.cityRibeirão Preto, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.date.issued2015-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume48pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage363pt_BR
dc.description.lastpage369pt_BR
dc.rightsAbertopt_BR
dc.sourceSciELOpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.eissn1414-431Xpt_BR
dc.identifier.doi10.1590/1414-431x20143619pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400363pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2021-01-06T12:18:44Z-
dc.date.accessioned2021-01-06T12:18:44Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-01-06T12:18:44Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:02:28Z : No. of bitstreams: 1 S0100-879X2015000400363.pdf: 298947 bytes, checksum: 67af836f7a08909495a642c86e304873 (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-06T12:18:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353722-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordChronic pelvic painpt_BR
dc.subject.keywordAbdominal myofascial pain syndromept_BR
dc.subject.keywordInflammationpt_BR
dc.subject.keywordCentral sensitizationpt_BR
dc.identifier.sourceS0100-879X2015000400363pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigopt_BR
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