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Type: Artigo
Title: Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis
Author: Rocha, M.G.
Gomes, V.A.
Tanus-Santos, J.E.
Rosa-e-Silva, J.C.
Candido-dos-Reis, F.J.
Nogueira, A.A.
Poli-Neto, O.B.
Abstract: The objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization.
Subject: Endometriose
Óxido nítrico
Country: Brasil
Editor: Associação Brasileira de Divulgação Científica
Rights: Aberto
Identifier DOI: 10.1590/1414-431x20143619
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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