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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPeixoto, Elisa Bouçada Mauro Inácio-
dc.contributor.authorunicampPapadimitriou, Alexandros-
dc.contributor.authorunicampToledo-Teixeira, Daniel Augusto de-
dc.contributor.authorunicampMontemurro, Chiara-
dc.contributor.authorunicampDuarte, Diego Andreazzi-
dc.contributor.authorunicampSilva, Kamila Cristina-
dc.contributor.authorunicampJoazeiro, Paulo Pinto-
dc.contributor.authorunicampFaria, Jacqueline Mendonça Lopes de-
dc.contributor.authorunicampFaria, Jose Butori Lopes de-
dc.typeArtigopt_BR
dc.titleReduced LRP6 expression and increase in the interaction of GSK3β with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green teapt_BR
dc.contributor.authorPeixoto, E.B.-
dc.contributor.authorPapadimitriou, A.-
dc.contributor.authorTeixeira, D.A.T.-
dc.contributor.authorMontemurro, C.-
dc.contributor.authorDuarte, D.A.-
dc.contributor.authorSilva, K.C.-
dc.contributor.authorJoazeiro, P.P.-
dc.contributor.authorFaria, J.M.Lopes de-
dc.contributor.authorFaria, J.B.Lopes de-
dc.subjectChá verdept_BR
dc.subjectNefropatias diabéticaspt_BR
dc.subject.otherlanguageGreen teapt_BR
dc.subject.otherlanguageDiabetic nephropathiespt_BR
dc.description.abstractIn diabetes mellitus (DM), podocyte apoptosis leads to albuminuria and nephropathy progression. Low-density lipoprotein receptor-related protein 6 (LRP6) is WNT pathway receptor that is involved in podocyte death, adhesion and motility. Glycogen synthase kinase 3 (GSK3) interaction with p53 (GSK3-p53) promotes apoptosis in carcinoma cells. It is unknown if GSK3-p53 contributes to podocyte apoptosis in DM. In experimental DM, green tea (GT) reduces albuminuria by an unknown mechanism. In the present study, we assessed the role of the GSK3β-p53 in podocyte apoptosis and the effects of GT on these abnormalities. In diabetic spontaneously hypertensive rats (SHRs), GT prevents podocyte's p-LRP6 expression reduction, increased GSK3β-p53 and high p53 levels. In diabetic SHR rats, GT reduces podocyte apoptosis, foot process effacement and albuminuria. In immortalized mouse podocytes (iMPs), high glucose (HG), silencing RNA (siRNA) or blocking LRP6 (DKK-1) reduced p-LRP6 expression, leading to high GSK3β-p53, p53 expression, apoptosis and increased albumin influx. GSK3β blockade by BIO reduced GSK3β-p53 and podocyte apoptosis. In iMPs under HG, GT reduced apoptosis and the albumin influx by blocking GSK3β-p53 following the rise in p-LRP6 expression. These effects of GT were prevented by LRP6 siRNA or DKK-1. In conclusion, in DM, WNT inhibition, via LRP6, increases GSK3β-p53 and podocyte apoptosis. Maneuvers that inactivate GSK3β-p53, such as GT, may be renoprotective in DM.pt_BR
dc.relation.ispartofThe journal of nutritional biochemistrypt_BR
dc.relation.ispartofabbreviationJ. nutr. biochem.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume26pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage416pt_BR
dc.description.lastpage430pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0955-2863pt_BR
dc.identifier.eissn1873-4847pt_BR
dc.identifier.doi10.1016/j.jnutbio.2014.11.012pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0955286315000029pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber304026/2013-1pt_BR
dc.description.sponsordocumentnumber2010/05841-5; 2008/57560-0pt_BR
dc.date.available2021-01-06T11:46:16Z-
dc.date.accessioned2021-01-06T11:46:16Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2021-01-06T11:46:16Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:02:27Z : No. of bitstreams: 1 000352463700014.pdf: 3413874 bytes, checksum: d5b4f0f8a8601ef56c62cba5c284243f (MD5)en
dc.description.provenanceMade available in DSpace on 2021-01-06T11:46:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353717-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeHospital de Clínicaspt_BR
dc.subject.keywordGSK3β (glycogen synthase kinase 3β)p53pt_BR
dc.identifier.source000352463700014pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-4055-058Xpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid000-0002-5079-4692pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4726-6159pt_BR
dc.creator.orcid0000-0002-4783-4665pt_BR
dc.creator.orcid0000-0003-2373-5539pt_BR
dc.type.formArtigopt_BR
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