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|Title:||Synthesis, antiproliferative activity and molecular properties predictions of galloyl derivatives|
|Author:||da Silva, Marciane Maximo|
Duarte, Thiago Santos
Foglio, Mary Ann
de Carvalho, Joao Ernesto
Vieira, Maria do Carmo
Nazari Formagio, Anelise Samara
|Abstract:||The present study was designed to investigate the in vitro antiproliferative activity against ten human cancer cell lines of a series of galloyl derivatives bearing substituted-1,3,4-oxadiazole and carbohydrazide moieties. The compounds were also assessed in an in silico study of the absorption, distribution, metabolism and excretion (ADME) in the human body using Lipinski's parameters, the topological polar surface area (TPSA) and percentage of absorption (%ABS). In general, the introduction of N'-(substituted)-arylidene galloyl hydrazides 4-8 showed a moderate antitumor activity, while the 2-methylthio- and 2-thioxo-1,3,4-oxadiazol-5-yl derivatives 9 and 10 led to increased inhibition of cancer cell proliferation. The precursor compound methyl gallate 2 and the intermediary galloyl hydrazide 3 showed greater antiproliferative activity with GI(50) values < 5.54 mu M against all human tumor cell lines tested. A higher inhibition effect against ovarian cancer (OVCAR-3) (GI(50) = 0.05-5.98 mu M) was also shown, with compounds 2, 3, 9 and 10 with GI(50) 0.89 mu M standing out in this respect. The in silico study revealed that the compounds showed good intestinal absorption|
|Appears in Collections:||CPQBA - Artigos e Outros Documentos|
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