Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353387
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSecolin, Rodrigo-
dc.contributor.authorunicampAraújo, Tiago Gomes-
dc.typeArtigopt_BR
dc.titleLack of association between the prothrombin RS1799963 polymorphism and juvenile myoclonic epilepsypt_BR
dc.contributor.authorLopes Born, Joao Paulo-
dc.contributor.authordos Santos, Bruna Priscila-
dc.contributor.authorSecolin, Rodrigo-
dc.contributor.authorde Andrade, Tiago Gomes-
dc.contributor.authorHerculano Machado, Luciana Claudia-
dc.contributor.authorGoes Gitai, Livia Leite-
dc.contributor.authorGoes Gitai, Daniel Leite-
dc.subjectEpilepsia mioclônica juvenilpt_BR
dc.subjectPolimorfismo (Genética)pt_BR
dc.subjectProtrombinapt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.subject.otherlanguageProthrombinpt_BR
dc.subject.otherlanguageJuvenile myoclonic epilepsypt_BR
dc.description.abstractJuvenile myoclonic epilepsy (JME) accounts for 26% of generalized idiopathic epileptic syndromes. The highest levels of thrombin activity are closely involved in the development of neurological diseases, including epilepsy. The prothrombin c.20210G>A (rs1799963) variation, which alters prothrombin mRNA stability, is associated with high plasma prothrombin levels. Objective: The present study was designed to investigate whether the SNP rs1799963 is a risk factor for JME in the northeastern Brazilian population. Results: The polymorphism was genotyped in 207 controls and 123 patients using polymerase chain reaction-restriction fragment length polymorphism method. No significant differences were observed in the genotype and allele frequencies of this polymorphism between cases and controls. Conclusion: These results present no evidence for an association of rs1799963 with JME. Further studies including other types of epilepsy are required to investigate the involvement of prothrombin gene in the genetic susceptibility to chronic seizurept_BR
dc.relation.ispartofArquivos de neuro-psiquiatriapt_BR
dc.relation.ispartofabbreviationArq. neuro-psiquiatr.pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssociação Arquivos de Neuro-Psiquiatriapt_BR
dc.date.issued2015-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume73pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage289pt_BR
dc.description.lastpage292pt_BR
dc.rightsAbertopt_BR
dc.sourceSCIELOpt_BR
dc.identifier.issn0004-282Xpt_BR
dc.identifier.eissn1678-4227pt_BR
dc.identifier.doi10.1590/0004-282X20150010pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000400289pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE ALAGOAS - FAPEALpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber60030-692/2009pt_BR
dc.date.available2020-12-22T17:55:20Z-
dc.date.accessioned2020-12-22T17:55:20Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-22T17:55:20Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:59:57Z : No. of bitstreams: 1 S0004-282X2015000400289.pdf: 200489 bytes, checksum: 3687d581e4423ca09f556a59e56384ee (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-22T17:55:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353387-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.sourceS0004-282X2015000400289pt_BR
dc.creator.orcid0000-0002-2485-9560pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
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