Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353344
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSippert, Emilia Ângela-
dc.contributor.authorunicampMarques, Silvia Barbosa Dutra-
dc.typeArtigopt_BR
dc.titleHla haplotypes and genotypes frequencies in brazilian chronic periodontitis patientspt_BR
dc.contributor.authorSippert, Emilia Angela-
dc.contributor.authorde Oliveira e Silva, Cleverson-
dc.contributor.authorAyo, Christiane Maria-
dc.contributor.authorDutra Marques, Silvia Barbosa-
dc.contributor.authorLaguila Visentainer, Jeane Eliete-
dc.contributor.authorSell, Ana Maria-
dc.subjectPeriodontitept_BR
dc.subjectPolimorfismo (Genética)pt_BR
dc.subject.otherlanguagePeriodontitispt_BR
dc.subject.otherlanguageGenetic polymorphismspt_BR
dc.description.abstractHuman leukocyte antigens (HLA) have a pivotal role in immune response and may be involved in antigen recognition of periodontal pathogens. However, the associations of HLA with chronic periodontitis (CP) have not been previously studied in the Brazilian population. In an attempt to clarify the issue of genetic predisposition to CP, we examined the distribution of HLA alleles, genotypes, and haplotypes in patients from Southern Brazil. One hundred and eight CP patients and 151 healthy and unrelated controls with age-, gender-, and ethnicity-matched were HLA investigated by polymerase chain reaction with sequence specific oligonucleotides. To exclude smoking as a predisposing factor, statistical analyses were performed in the total sample and in nonsmoking individuals. The significant results showed a positive association of the A*02/HLA-B*40 haplotype with CP (total samples: 4.2% versus 0%, P-c = 0.03; nonsmokers: 4.3% versus 0%, P-c = 0.23) and a lower frequency of HLA-B*15/HLA-DRB1*11 haplotype in CP compared to controls (total samples: 0.0% versus 4.3%, P-c = 0.04; nonsmokers: 0 versus 5.1%, P-c = 1.0). In conclusion, the HLA-A*02/B*40 haplotype may contribute to the development of CP, while HLA-B*15/DRB1*11 haplotype might indicate resistance to disease among Brazilianspt_BR
dc.relation.ispartofMediators of inflammationpt_BR
dc.relation.ispartofabbreviationMediators inflammpt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherHindawipt_BR
dc.date.issued2015-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume2015pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0962-9351pt_BR
dc.identifier.eissn1466-1861pt_BR
dc.identifier.doi10.1155/2015/481656pt_BR
dc.identifier.urlhttps://www.hindawi.com/journals/mi/2015/481656/pt_BR
dc.date.available2020-12-21T17:34:36Z-
dc.date.accessioned2020-12-21T17:34:36Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-21T17:34:36Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:59:54Z : No. of bitstreams: 1 000359572700001.pdf: 1387274 bytes, checksum: b40ec1b378dd00286c9e8c6c359bfcb6 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-21T17:34:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353344-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000359572700001pt_BR
dc.creator.orcid0000-0002-6341-3879pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid481656pt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
HEMO - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000359572700001.pdf1.35 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.