Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353343
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampNery, Mariana Freitas-
dc.typeArtigopt_BR
dc.titleMolecular evolution of hoxa13 and the multiple origins of limbless morphologies in amphibians and reptilespt_BR
dc.contributor.authorSingarete, Marina E.-
dc.contributor.authorGrizante, Mariana B.-
dc.contributor.authorMilograna, Sarah R.-
dc.contributor.authorNery, Mariana F.-
dc.contributor.authorKin, Koryu-
dc.contributor.authorWagner, Guenter P.-
dc.contributor.authorKohlsdorf, Tiana-
dc.subjectAnálise filogenéticapt_BR
dc.subjectSeleção positivapt_BR
dc.subject.otherlanguagePhylogenetic analysispt_BR
dc.subject.otherlanguagePositive selectionpt_BR
dc.description.abstractDevelopmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to different roles, the situation for proteins is less clear, being particularly complex for transcription factors with multiple functions. Some motifs mediating protein-protein interactions may be exclusive to particular developmental roles, but it is also possible that motifs are mostly shared among different processes. Here we focus on HoxA13, a protein essential for limb development. We asked whether the HoxA13 amino acid sequence evolved similarly in three limbless clades: Gymnophiona, Amphisbaenia and Serpentes. We explored variation in omega (dN/dS) using a maximum-likelihood framework and HoxA13 sequences from 47 species. Comparisons of evolutionary models provided low omega global values and no evidence that HoxA13 experienced relaxed selection in limbless clades. Branch-site models failed to detect evidence for positive selection acting on any site along branches of Amphisbaena and Gymnophiona, while three sites were identified in Serpentes. Examination of alignments did not reveal consistent sequence differences between limbed and limbless species. We conclude that HoxA13 has no modules exclusive to limb development, which may be explained by its involvement in multiple developmental processespt_BR
dc.relation.ispartofGenetics and molecular biologypt_BR
dc.relation.ispartofabbreviationGenet. mol. biol.pt_BR
dc.publisher.cityRibeirão Preto, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSociedade Brasileira de Genéticapt_BR
dc.date.issued2015-
dc.date.monthofcirculationJul.pt_BR
dc.language.isoengpt_BR
dc.description.volume38pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage255pt_BR
dc.description.lastpage262pt_BR
dc.rightsAbertopt_BR
dc.sourceSCIELOpt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.eissn1678-4685pt_BR
dc.identifier.doi10.1590/S1415-475738320150039pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?pid=S1415-47572015000300255&script=sci_arttextpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber563232/2010-2pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2010/00447-7; 2012/13165-5; 2011/18868-1; 2010/52316-3pt_BR
dc.date.available2020-12-21T17:23:16Z-
dc.date.accessioned2020-12-21T17:23:16Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-21T17:23:16Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:59:54Z : No. of bitstreams: 1 S1415-47572015000300255.pdf: 318637 bytes, checksum: 801f7b7de9833b61675ea122e46143fb (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-21T17:23:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353343-
dc.contributor.departmentDepartamento de Genética, Evolução, Microbiologia e Imunologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.sourceS1415-47572015000300255pt_BR
dc.creator.orcid0000-0001-6501-0486pt_BR
dc.type.formArtigo de pesquisapt_BR
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