Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353330
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampPaiatto, Lisiery Negrini-
dc.contributor.authorunicampFernandes, Luis Gustavo Romani-
dc.contributor.authorunicampTamashiro, Wirla Maria da Silva Cunha-
dc.contributor.authorunicampSimioni, Patricia Ucelli-
dc.typeArtigopt_BR
dc.titleTolerogenic dendritic cells on transplantation: immunotherapy based on second signal blockagept_BR
dc.contributor.authorSilva, Priscila de Matos-
dc.contributor.authorBier, Julia-
dc.contributor.authorPaiatto, Lisiery Negrini-
dc.contributor.authorAlbuquerque, Cassia Galdino-
dc.contributor.authorSouza, Caique Lopes-
dc.contributor.authorRomani Fernandes, Luis Gustavo-
dc.contributor.authorda Silva Cunha Tamashiro, Wirla Maria-
dc.contributor.authorSimioni, Patricia Ucelli-
dc.subjectLinfócitos T reguladorespt_BR
dc.subjectCélulas matadoras naturaispt_BR
dc.subject.otherlanguageT-Lymphocytes, regulatorypt_BR
dc.subject.otherlanguageKiller cells, Naturalpt_BR
dc.description.abstractDendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection. In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development. This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection. However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profilept_BR
dc.relation.ispartofJournal of immunology researchpt_BR
dc.relation.ispartofabbreviationJ. immunol. res.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherHindawipt_BR
dc.date.issued2015-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume2015pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2314-8861pt_BR
dc.identifier.eissn2314-7156pt_BR
dc.identifier.doi10.1155/2015/856707pt_BR
dc.identifier.urlhttps://www.hindawi.com/journals/jir/2015/856707/pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2013/20258; 2014/08591-0; 2014/16701-0; 2014/08619-2pt_BR
dc.date.available2020-12-21T14:21:10Z-
dc.date.accessioned2020-12-21T14:21:10Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-21T14:21:10Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:59:53Z : No. of bitstreams: 1 000363575300001.pdf: 1930690 bytes, checksum: de01af20a401590fe55b8894eb2dfa4a (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-21T14:21:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353330-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.identifier.source000363575300001pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0771-1027pt_BR
dc.creator.orcid0000-0001-8023-9027pt_BR
dc.creator.orcid0000-0002-6951-5040pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid856707pt_BR
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