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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampTanus-Santos, Jose Eduardo-
dc.typeArtigopt_BR
dc.titleCorrelations among antiangiogenic factors and trace elements in hypertensive disorders of pregnancypt_BR
dc.contributor.authorRezende, Vania B.-
dc.contributor.authorBarbosa Junior, Fernando-
dc.contributor.authorPalei, Ana C.-
dc.contributor.authorCavalli, Ricardo C.-
dc.contributor.authorTanus-Santos, Jose E.-
dc.contributor.authorSandrim, Valeria C.-
dc.subjectPré-eclâmpsiapt_BR
dc.subjectMarcadores biológicospt_BR
dc.subject.otherlanguagePre-Eclampsiapt_BR
dc.subject.otherlanguageBiological markerspt_BR
dc.description.abstractAlthough a number of studies have measured circulating levels of some trace elements in preeclampsia (PE) and compared to healthy pregnant (HP), there is no consensus yet about the deficiency of some metals and development of hypertensive disorders in pregnancy. The aim of this study was to compare plasmatic levels of Zn, Mn, Co, Cu, Se and Sr among non-pregnant (NP), healthy pregnant (HP), gestational hypertensive (GH) and preeclamptic (PE) women and to correlate these levels with plasma soluble endoglin (sENG) and soluble fms-like tyrosine kinase-1 (sFLT-1), two important antiangiogenic proteins related to PE. A total of 184 women were enrolled in this study (NP = 35, GH = 51, PE = 37 and HP = 61). Trace element analyses were carried out with an inductively coupled plasma mass spectrometer (ICPMS). sENG and sFLT-1 plasma concentrations were measured by commercial ELISA kits. The most interesting result is that Sr is higher in PE (63%, P<0.001) compared to HP and their levels are positively correlated with sENG in all three groups of pregnant women. Moreover, we found a negative correlation between Zn and sENG in HP (r=-0.43, P=0.003). Regarding other elements, we found similar levels among pregnant groups. In conclusion, this study showed that Sr may has a role in physiopathology of PEpt_BR
dc.relation.ispartofJournal of trace elements in medicine and biologypt_BR
dc.relation.ispartofabbreviationJ. trace elem. med. biol.pt_BR
dc.publisher.cityMuenchenpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume29pt_BR
dc.description.firstpage130pt_BR
dc.description.lastpage135pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0946-672Xpt_BR
dc.identifier.eissn1878-3252pt_BR
dc.identifier.doi10.1016/j.jtemb.2014.06.011pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0946672X14001163pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.date.available2020-12-17T19:46:41Z-
dc.date.accessioned2020-12-17T19:46:41Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-17T19:46:41Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-19T18:59:49Z : No. of bitstreams: 1 000347498000017.pdf: 416804 bytes, checksum: f35760ed706ac4b538bccb439c665b5f (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-17T19:46:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353250-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000347498000017pt_BR
dc.creator.orcid0000-0002-9945-9633pt_BR
dc.type.formArtigopt_BR
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