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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGeloneze Neto, Bruno-
dc.typeArtigopt_BR
dc.titleSupplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetespt_BR
dc.contributor.authorGomes, Patricia M.-
dc.contributor.authorHollanda-Miranda, Wallace R.-
dc.contributor.authorBeraldo, Rebeca A.-
dc.contributor.authorCastro, Ana V. B.-
dc.contributor.authorGeloneze, Bruno-
dc.contributor.authorFoss, Milton C.-
dc.contributor.authorFoss-Freitas, Maria C.-
dc.subjectResistência à insulinapt_BR
dc.subject.otherlanguageInsulin resistancept_BR
dc.description.abstractObjective: omega-3 Polyunsaturated a-linolenic acid (ALA) supplementation has not been studied in the setting of adiponectin levels and insulin sensitivity (IS) improvements in patients with type 2 diabetes mellitus (T2DM) by hyperinsulinemic-euglycemic clamp (HEC). The aim of this study was to examine the influence of w-3 ALA on IS and adiponectin. Methods: We conducted a randomized study in patients with T2DM and assessed IS using HEC. Twenty patients with T2DM were included and randomly assigned to receive 3 g/d of ALA or placebo for 60 d, in a double-blind design. The assessment of IS by HEC was performed at baseline and after 60 d in all patients; blood samples were taken for the measurement of serum lipids, glucose, insulin, adiponectin, and cytokines. The primary outcome variables were an increase of both glucose infusion rate (GIR) in steady state and glucose metabolization (M) by HEC. The secondary outcomes were an increase in adiponectin levels and a decrease in fasting plasma glucose, glycated hemoglobin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipids and cytokines. The study was conducted at an academic medical center. Results: The ALA group improved IS corrected for fat-free mass (M/FFM; P = 0.04). Both groups showed increased adiponectin after 60 d (P = 0.01), however, the increase for the ALA group was greater (P = 0.04). In the ALA group, adiponectin was positively correlated with GIR (r = 0.76; P= 0.01) and M/FFM (r = 0.62; P = 0.06), and negatively correlated with HOMA-IR (r = 0.61; P = 0.03). Conclusion: omega-3 ALA supplementation improved glucose homeostasis and was associated with an increase in adiponectin. Improvement in the overall metabolic profile with omega-3 ALA suggests a potential clinical utility for this agent and requires further investigationpt_BR
dc.relation.ispartofNutritionpt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2015-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume31pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage853pt_BR
dc.description.lastpage857pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0899-9007pt_BR
dc.identifier.eissn1873-1244pt_BR
dc.identifier.doi10.1016/j.nut.2014.12.028pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0899900715000404pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber14/2012pt_BR
dc.description.sponsordocumentnumber2011/09640-7pt_BR
dc.date.available2020-12-17T11:14:21Z-
dc.date.accessioned2020-12-17T11:14:21Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-12-17T11:14:21Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-25T19:55:31Z : No. of bitstreams: 1 000354342900012.pdf: 3002746 bytes, checksum: 25625e9300ec890a3e472c2d65905630 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-17T11:14:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353217-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordType 2 diabetes mellituspt_BR
dc.subject.keywordInsulin resistancept_BR
dc.subject.keywordHyperinsulinemic-euglycemic clamppt_BR
dc.subject.keywordAdiponectinpt_BR
dc.subject.keywordAlpha-Linolenic acidpt_BR
dc.identifier.source000354342900012pt_BR
dc.creator.orcid0000-0002-0557-4578pt_BR
dc.type.formArtigopt_BR
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