Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353208
Type: Artigo
Title: Serum Interleukin-17 levels are associated with nephritis in childhood-onset systemic Lupus Erythematosus
Author: Pelicari, Karina de Oliveira
Postal, Mariana
Sinicato, Nailu Angelica
Peres, Fernando Augusto
Fernandes, Paula Teixeira
Marini, Roberto
Lavras Costallat, Lilian Tereza
Appenzeller, Simone
Abstract: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age- and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p=0.009). We observed an association between serum IL-17 levels and active nephritis (p=0.01) and migraines (p=0.03). Serum IL-17 levels were not associated with disease activity (p=0.32), cumulative damage (p=0.34), or medication use (p=0.63). IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus
Subject: Interleucina-17
Lúpus eritematoso sistêmico juvenil
Country: Brasil
Editor: USP
Rights: Aberto
Identifier DOI: 10.6061/clinics/2015(05)01
Address: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000500313
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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