Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353158
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMedina, Flavio Mac Cord-
dc.contributor.authorunicampMelo, Mônica Barbosa de-
dc.typeArtigopt_BR
dc.titlePharmacogenetic effect of complement factor H gene polymorphism in response to the initial intravitreal injection of bevacizumab for wet age-related macular degenerationpt_BR
dc.contributor.authorMedina, Flavio Mac Cord-
dc.contributor.authorLopes da Motta, Augusto Alves-
dc.contributor.authorTakahashi, Walter Y.-
dc.contributor.authorCarricondo, Pedro Carlos-
dc.contributor.authordos Santos Motta, Mario Martins-
dc.contributor.authorMelo, Monica B.-
dc.contributor.authorVasconcellos, Jose Paulo C.-
dc.subjectBevacizumabpt_BR
dc.subjectDegeneração macularpt_BR
dc.subject.otherlanguageMacular degenerationpt_BR
dc.subject.otherlanguageBevacizumabpt_BR
dc.description.abstractTo compare the functional and morphological response to the initial intravitreal (IV) injection of bevacizumab in exudative age-related macular degeneration (AMD) patients with the complement factor H (CFH) gene polymorphism T1277C in the Brazilian population. Twenty-five unrelated patients with treatment-naive exudative AMD underwent an IVT injection of 1.25 mg bevacizumab at the initial presentation (DO) and were reexamined 7 days (D7) and 28 days (D28) later. The time and extent of visual acuity (VA) and central retinal thickness (CRT) changes were evaluated according to the presence of the T1277C polymorphism. Results: In the homozygous risk group (CC), VA improvement was detected mostly from D7 to D28, while in the heterozygous (CT) and homozygous for the wild-type allele (TT) groups, functional response occurred earlier, from DO to D7. Morphological response to the first IVT injection of bevacizunnab was significant in the CT and TT groups, while the CC group presented no significant change in CRT up to D28. The CC variant of the CFH gene polymorphism T1277C is related to delayed functional and limited morphological response to the initial IVT injection of bevacizumab in exudative AMD patients in a sample of the Brazilian populationpt_BR
dc.relation.ispartofOphthalmic researchpt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuiçapt_BR
dc.publisherKargerpt_BR
dc.date.issued2015-
dc.language.isoengpt_BR
dc.description.volume54pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage169pt_BR
dc.description.lastpage174pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0030-3747pt_BR
dc.identifier.eissn0030-3747pt_BR
dc.identifier.doi10.1159/000439172pt_BR
dc.identifier.urlhttps://www.karger.com/Article/Abstract/439172pt_BR
dc.date.available2020-12-14T16:38:30Z-
dc.date.accessioned2020-12-14T16:38:30Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-12-14T16:38:30Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-06-30T17:36:59Z : No. of bitstreams: 1 000365379300001.pdf: 292272 bytes, checksum: 78d0f61eb078b100a103f46b2c8494ef (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-14T16:38:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353158-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeCentro de Biologia Molecular e Engenharia Genéticapt_BR
dc.subject.keywordPharmacogeneticspt_BR
dc.subject.keywordComplement factor H genept_BR
dc.identifier.source000365379300001pt_BR
dc.creator.orcid0000-0001-5694-7007pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo originalpt_BR
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