Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353155
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRibeiro, Aline Rimoldi-
dc.typeArtigopt_BR
dc.titleAntiprotozoal activity of the cyclopalladated complexes against leishmania amazonensis and trypanosoma cruzipt_BR
dc.contributor.authorVelásquez, Angela M. A.-
dc.contributor.authorSouza, Rodrigo A. de-
dc.contributor.authorPassalacqua, Thaís G.-
dc.contributor.authorRibeiro, Aline R.-
dc.contributor.authorScontri, Mateus-
dc.contributor.authorChin, Chung M.-
dc.contributor.authorAlmeida, Leticia de-
dc.contributor.authorCistia, Mayara L. Del-
dc.contributor.authorRosa, João A. da-
dc.contributor.authorMauro, Antonio E.-
dc.contributor.authorGraminha, Marcia A. S.-
dc.subjectDoença de Chagaspt_BR
dc.subject.otherlanguageChagas diseasept_BR
dc.description.abstractThe present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(μ-Cl)]2, [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N3)(isn)] and [Pd(dmba)(μ-NCO)]2, (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(μ-NCO)]2 exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC50) value of less than 9 µM and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(μ-NCO)]2 is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas diseasept_BR
dc.relation.ispartofJournal of the Brazilian chemical societypt_BR
dc.relation.ispartofabbreviationJ. Braz. chem. soc.pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.date.issued2016-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume27pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage1032pt_BR
dc.description.lastpage1039pt_BR
dc.rightsAbertopt_BR
dc.sourceSciELOpt_BR
dc.identifier.issn0103-5053pt_BR
dc.identifier.eissn1678-4790pt_BR
dc.identifier.doi10.5935/0103-5053.20150360pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000601032pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumber201308248-1pt_BR
dc.date.available2020-12-14T14:17:33Z-
dc.date.accessioned2020-12-14T14:17:33Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-12-14T14:17:33Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-12-14T14:17:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353155-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordCyclopalladatedpt_BR
dc.subject.keywordLeishmaniasispt_BR
dc.subject.keywordLeishmania amazonensispt_BR
dc.subject.keywordTrypanosoma cruzipt_BR
dc.subject.keywordTrypanosomiasispt_BR
dc.identifier.sourceS0103-50532016000601032pt_BR
dc.creator.orcid0000-0003-0405-3399pt_BR
dc.type.formArtigopt_BR
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