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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSouza, Carmino Antonio de-
dc.typeArtigopt_BR
dc.titleImprovement in the outcome of invasive fusariosis in the last decadept_BR
dc.contributor.authorNucci, M.-
dc.contributor.authorMarr, K. A.-
dc.contributor.authorVehreschild, M. J. G. T.-
dc.contributor.authorde Souza, C. A.-
dc.contributor.authorVelasco, E.-
dc.contributor.authorCappellano, P.-
dc.contributor.authorCarlesse, F.-
dc.contributor.authorQueiroz-Telles, F.-
dc.contributor.authorSheppard, D. C.-
dc.contributor.authorKindo, A.-
dc.contributor.authorCesaro, S.-
dc.contributor.authorHamerschlak, N.-
dc.contributor.authorSolza, C.-
dc.contributor.authorHeinz, W. J.-
dc.contributor.authorSchaller, M.-
dc.contributor.authorAtalla, A.-
dc.contributor.authorArikan-Akdagli, S.-
dc.contributor.authorBertz, H.-
dc.contributor.authorGalvão Castro, C.-
dc.contributor.authorHerbrecht, R.-
dc.contributor.authorHoenigl, M.-
dc.contributor.authorHärter, G.-
dc.contributor.authorHermansen, N. E. U.-
dc.contributor.authorJosting, A.-
dc.contributor.authorPagano, L.-
dc.contributor.authorSalles, M. J. C.-
dc.contributor.authorMossad, S. B.-
dc.contributor.authorOgunc, D.-
dc.contributor.authorPasqualotto, A. C.-
dc.contributor.authorAraujo, V.-
dc.contributor.authorTroke, P. F.-
dc.contributor.authorLortholary, O.-
dc.contributor.authorCornely, O. A.-
dc.contributor.authorAnaissie, E.-
dc.subjectVoriconazolpt_BR
dc.subject.otherlanguageVoriconazolept_BR
dc.description.abstractInvasive fusariosis (IF) has been associated with a poor prognosis. Although recent series have reported improved outcomes, the definition of optimal treatments remains controversial. The objective of this study was to evaluate changes in the outcome of IF. We retrospectively analysed 233 cases of IF from 11 countries, comparing demographics, clinical findings, treatment and outcome in two periods: 1985–2000 (period 1) and 2001–2011 (period 2). Most patients (92%) had haematological disease. Primary treatment with deoxycholate amphotericin B was more frequent in period 1 (63% vs. 30%, p <0.001), whereas voriconazole (32% vs. 2%, p <0.001) and combination therapies (18% vs. 1%, p <0.001) were more frequent in period 2. The 90-day probabilities of survival in periods 1 and 2 were 22% and 43%, respectively (p <0.001). In period 2, the 90-day probabilities of survival were 60% with voriconazole, 53% with a lipid formulation of amphotericin B, and 28% with deoxycholate amphotericin B (p 0.04). Variables associated with poor prognosis (death 90 days after the diagnosis of fusariosis) by multivariable analysis were: receipt of corticosteroids (hazard ratio (HR) 2.11, 95% CI 1.18–3.76, p 0.01), neutropenia at end of treatment (HR 2.70, 95% CI 1.57–4.65, p <0.001), and receipt of deoxycholate amphotericin B (HR 1.83, 95% CI 1.06–3.16, p 0.03). Treatment practices have changed over the last decade, with an increased use of voriconazole and combination therapies. There has been a 21% increase in survival rate in the last decadept_BR
dc.relation.ispartofClinical microbiology and infectionpt_BR
dc.relation.ispartofabbreviationClin microbiol infectpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume20pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage580pt_BR
dc.description.lastpage585pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1198-743Xpt_BR
dc.identifier.eissn1469-0691pt_BR
dc.identifier.doi10.1111/1469-0691.12409pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1198743X14641914pt_BR
dc.date.available2020-12-11T15:10:42Z-
dc.date.accessioned2020-12-11T15:10:42Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-12-11T15:10:42Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-25T19:55:35Z : No. of bitstreams: 1 2-s2.0-84904434174.pdf: 5905946 bytes, checksum: eee9c8e8de7bd0cd6c2d5db46890889d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-11T15:10:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353115-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeCentro de Hematologia e Hemoterapiapt_BR
dc.subject.keywordEpidemiologypt_BR
dc.subject.keywordFusariosispt_BR
dc.subject.keywordOutcomept_BR
dc.subject.keywordTreatmentpt_BR
dc.identifier.source2-s2.0-84904434174pt_BR
dc.creator.orcid0000-0001-8656-8374pt_BR
dc.type.formArtigo originalpt_BR
dc.description.otherSponsorshipsem informaçãopt_BR
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