Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/353094
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampKido, Larissa Akemi-
dc.contributor.authorunicampHetzl, Amanda Cia-
dc.contributor.authorunicampCândido, Eduardo Marcelo-
dc.contributor.authorunicampMontico, Fabio-
dc.contributor.authorunicampLorencini, Raísa Mistieri-
dc.contributor.authorunicampCagnon, Valéria Helena Alves-
dc.typeArtigopt_BR
dc.titleAntiangiogenic and finasteride therapies: Responses of the prostate microenvironment in elderly micept_BR
dc.contributor.authorKido, Larissa Akemi-
dc.contributor.authorHetzl, Amanda Cia-
dc.contributor.authorCândido, Eduardo Marcelo-
dc.contributor.authorMontico, Fabio-
dc.contributor.authorLorencini, Raísa Mistieri-
dc.contributor.authorCagnon, Valéria Helena Alves-
dc.subjectPróstatapt_BR
dc.subject.otherlanguageProstatept_BR
dc.description.abstractAims The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. Main methods 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20 mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416 + TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. Key findings The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416 + TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. Significance The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416 + TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-βpt_BR
dc.relation.ispartofLife sciencespt_BR
dc.relation.ispartofabbreviationLife scipt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume106pt_BR
dc.description.issuenumber1-2pt_BR
dc.description.firstpage58pt_BR
dc.description.lastpage70pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn0024-3205pt_BR
dc.identifier.eissn1879-0631pt_BR
dc.identifier.doi10.1016/j.lfs.2014.04.027pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0024320514004470pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2011/03116-4; 2012/03010-4pt_BR
dc.date.available2020-12-10T19:44:28Z-
dc.date.accessioned2020-12-10T19:44:28Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-12-10T19:44:28Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-25T19:55:34Z : No. of bitstreams: 1 2-s2.0-84901689452.pdf: 33436278 bytes, checksum: 57e0d2c9133d4da70970d833adb8eaa3 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-10T19:44:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353094-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAntiangiogenicpt_BR
dc.subject.keywordFinasteridept_BR
dc.subject.keywordAgingpt_BR
dc.subject.keywordHormone receptorpt_BR
dc.identifier.source2-s2.0-84901689452pt_BR
dc.creator.orcid0000-0002-3653-8035pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-8360-0842pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-5331-7376pt_BR
dc.type.formArtigopt_BR
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