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Type: Artigo
Title: High 15-f-2t-isoprostane levels in patients with a previous history of nonmelanoma skin cancer: the effects of supplementary antioxidant therapy
Author: de Almendra Freitas, Betania de Jesus e Silva
Lloret, Gustavo Rafaini
Visacri, Marilia Berlofa
Tuan, Bruna Taliani
Amaral, Lais Sampaio
Baldini, Daniele
de Sousa, Vanessa Marcilio
de Castro, Lais Lima
Sousa Aguiar, Jordana Rayane
Pincinato, Eder de Carvalho
Mazzola, Priscila Gava
Moriel, Patricia
Abstract: Phase I of this study was aimed at comparing the profiles of oxidative stress biomarkers in patients with history of nonmelanoma skin cancer (NMSC), previously treated with surgery, to the healthy subjects. Phase II aimed to evaluate the effects of supplementary antioxidant therapy on the levels of biomarkers in the case group. In Phase I, oxidative stress biomarkers were measured in blood samples obtained from 24 healthy subjects and 60 patients with history of NMSC previously treated with surgery. In Phase II, the 60 patients with history of NMSC were randomized into two subgroups, one receiving placebo (n = 34) and the other (n = 26) receiving vitamin C, vitamin E, and zinc supplementation for 8 weeks, followed by reevaluation of biomarkers. Results. In Phase I, patients with history of NMSC showed increased plasma concentrations of all biomarkers, but only 15-F-2t-isoprostane was significantly higher than in the healthy subjects. Risk of NMSC increased by 4% for each additional 1 pg/mL increase in 15-F-2t-isoprostane. In Phase II, supplementation did not significantly reduce levels of oxidative stress biomarkers. Patients with history of NMSC had significantly high 15-F-2t-isoprostane plasma levels; supplementation did not result in significant reduction of oxidative stress biomarkers. This trial was registered with (ID NCT02248584)
Subject: Peroxidação de lipídeos
Marcadores biológicos
Estresse oxidativo
Country: Reino Unido
Editor: Hindawi
Rights: Aberto
Identifier DOI: 10.1155/2015/963569
Date Issue: 2015
Appears in Collections:FCM - Artigos e Outros Documentos

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