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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBrito, Alba Regina Monteiro Souza-
dc.typeArtigopt_BR
dc.titleSafflower oil: An integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicitypt_BR
dc.contributor.authorToma, Walber-
dc.contributor.authorGuimarães, Luciana L.-
dc.contributor.authorBrito, Alba R. M. S.-
dc.contributor.authorSantos, Aldo R.-
dc.contributor.authorCortez, Fernando S.-
dc.contributor.authorPusceddu, Fábio H.-
dc.contributor.authorCesar, Augusto-
dc.contributor.authorJúnior, Landulfo S.-
dc.contributor.authorPacheco, Marcos T. T.-
dc.contributor.authorPereira, Camilo D. S.-
dc.subjectToxicologia ambientalpt_BR
dc.subject.otherlanguageEnvironmental toxicologypt_BR
dc.description.abstractGastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spec- troscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) de- crease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). More- over, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests per- formed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new noti-fied substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathologypt_BR
dc.relation.ispartofRevista brasileira de farmacognosiapt_BR
dc.publisher.cityJoão Pessoa, PBpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherElsevierpt_BR
dc.date.issued2014-
dc.date.monthofcirculationSep./Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume24pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage538pt_BR
dc.description.lastpage544pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn0102-695Xpt_BR
dc.identifier.eissn1981-528Xpt_BR
dc.identifier.doi10.1016/j.bjp.2014.09.004pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0102695X1400074Xpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2009/01788-5pt_BR
dc.date.available2020-12-09T17:56:07Z-
dc.date.accessioned2020-12-09T17:56:07Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-12-09T17:56:07Z No. of bitstreams: 0. Added 1 bitstream(s) on 2021-02-25T19:55:27Z : No. of bitstreams: 1 2-s2.0-84918555193.pdf: 4317172 bytes, checksum: 0f345a85f72f6305b7c5b2c9eb6e3263 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-12-09T17:56:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/353025-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAntiulcerogenic activitypt_BR
dc.subject.keywordRaman spectroscopypt_BR
dc.subject.keywordSafflower oilpt_BR
dc.subject.keywordToxicologypt_BR
dc.identifier.source2-s2.0-84918555193pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigo originalpt_BR
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